Abstract

The differential diagnosis of inflammatory bowel disease remains a significant diagnostic problem for surgical pathologists. Neural abnormalities, such as hypertrophy of nerve plexi, hyperplasia of ganglion cells, and ultrastructural axonal degeneration have been described in patients with regional enteritis. We performed an immunohistochemical survey of forty cases of regional enteritis, ulcerative colitis, nonspecific colitis, and normal colon. A panel of antibodies, directed against neuron-specific enolase, S-100 protein, synaptophysin, neurofilament protein, and nerve growth factor receptor, was utilized to evaluate the distribution of nerve fibers in paraffin-embedded tissue. Anti-synaptophysin and anti-nerve growth factor receptor highlighted small, arborizing nerve fibers in the mucosa, not apparent in the routinely stained sections. Intense staining of these fibers was observed in regional enteritis with antinerve growth factor receptor. This antibody may aid the discrimination of inflammatory bowel disease from other causes of colonic inflammation and facilitate the identification of regional enteritis in endoscopic biopsies.

Original languageEnglish (US)
Pages (from-to)488-493
Number of pages6
JournalModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Volume3
Issue number4
StatePublished - Jul 1 1990

Fingerprint

Inflammatory Bowel Diseases
Crohn Disease
Nerve Growth Factor Receptor
Nerve Fibers
Neurofilament Proteins
Synaptophysin
Growth Factor Receptors
S100 Proteins
Phosphopyruvate Hydratase
Antibodies
Colitis
Ulcerative Colitis
Ganglia
Paraffin
Hypertrophy
Hyperplasia
Colon
Mucous Membrane
Differential Diagnosis
Staining and Labeling

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

@article{c85dcb2301174b3b8fa3f67c050668b2,
title = "Neural patterns in inflammatory bowel disease: an immunohistochemical survey.",
abstract = "The differential diagnosis of inflammatory bowel disease remains a significant diagnostic problem for surgical pathologists. Neural abnormalities, such as hypertrophy of nerve plexi, hyperplasia of ganglion cells, and ultrastructural axonal degeneration have been described in patients with regional enteritis. We performed an immunohistochemical survey of forty cases of regional enteritis, ulcerative colitis, nonspecific colitis, and normal colon. A panel of antibodies, directed against neuron-specific enolase, S-100 protein, synaptophysin, neurofilament protein, and nerve growth factor receptor, was utilized to evaluate the distribution of nerve fibers in paraffin-embedded tissue. Anti-synaptophysin and anti-nerve growth factor receptor highlighted small, arborizing nerve fibers in the mucosa, not apparent in the routinely stained sections. Intense staining of these fibers was observed in regional enteritis with antinerve growth factor receptor. This antibody may aid the discrimination of inflammatory bowel disease from other causes of colonic inflammation and facilitate the identification of regional enteritis in endoscopic biopsies.",
author = "Strobach, {R. S.} and Ross, {A. H.} and Markin, {Rodney Smith} and Zetterman, {Rowen K} and James Linder",
year = "1990",
month = "7",
day = "1",
language = "English (US)",
volume = "3",
pages = "488--493",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Neural patterns in inflammatory bowel disease

T2 - an immunohistochemical survey.

AU - Strobach, R. S.

AU - Ross, A. H.

AU - Markin, Rodney Smith

AU - Zetterman, Rowen K

AU - Linder, James

PY - 1990/7/1

Y1 - 1990/7/1

N2 - The differential diagnosis of inflammatory bowel disease remains a significant diagnostic problem for surgical pathologists. Neural abnormalities, such as hypertrophy of nerve plexi, hyperplasia of ganglion cells, and ultrastructural axonal degeneration have been described in patients with regional enteritis. We performed an immunohistochemical survey of forty cases of regional enteritis, ulcerative colitis, nonspecific colitis, and normal colon. A panel of antibodies, directed against neuron-specific enolase, S-100 protein, synaptophysin, neurofilament protein, and nerve growth factor receptor, was utilized to evaluate the distribution of nerve fibers in paraffin-embedded tissue. Anti-synaptophysin and anti-nerve growth factor receptor highlighted small, arborizing nerve fibers in the mucosa, not apparent in the routinely stained sections. Intense staining of these fibers was observed in regional enteritis with antinerve growth factor receptor. This antibody may aid the discrimination of inflammatory bowel disease from other causes of colonic inflammation and facilitate the identification of regional enteritis in endoscopic biopsies.

AB - The differential diagnosis of inflammatory bowel disease remains a significant diagnostic problem for surgical pathologists. Neural abnormalities, such as hypertrophy of nerve plexi, hyperplasia of ganglion cells, and ultrastructural axonal degeneration have been described in patients with regional enteritis. We performed an immunohistochemical survey of forty cases of regional enteritis, ulcerative colitis, nonspecific colitis, and normal colon. A panel of antibodies, directed against neuron-specific enolase, S-100 protein, synaptophysin, neurofilament protein, and nerve growth factor receptor, was utilized to evaluate the distribution of nerve fibers in paraffin-embedded tissue. Anti-synaptophysin and anti-nerve growth factor receptor highlighted small, arborizing nerve fibers in the mucosa, not apparent in the routinely stained sections. Intense staining of these fibers was observed in regional enteritis with antinerve growth factor receptor. This antibody may aid the discrimination of inflammatory bowel disease from other causes of colonic inflammation and facilitate the identification of regional enteritis in endoscopic biopsies.

UR - http://www.scopus.com/inward/record.url?scp=0025455110&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025455110&partnerID=8YFLogxK

M3 - Article

C2 - 2217153

AN - SCOPUS:0025455110

VL - 3

SP - 488

EP - 493

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 4

ER -