Neural influences on renal responses to acute volume expansion in rats with heart failure

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Abstract

Experiments were performed to test the postulate that neural influences underlie the suppressed excretory response to acute volume expansion (VE) typically observed 3-4 wk after myocardial infarction to induce chronic heart failure (CHF). Responses to VE were assessed in innervated (intact) and denervated (DNX) kidneys of anesthetized CHF rats and sham-operated controls. CHF rats exhibited blunted natriuretic responses to VE in both intact kidneys (35% of sham response) and DNX kidneys (55% of sham DNX response). CHF rats also displayed suppressed excretory responses to atrial natriuretic factor (0.25 μg · kg-1 · min-1 iv) in both intact kidneys (74% of sham response) and DNX kidneys (63% of sham DNX response). Additional experiments confirmed that the compliance of the venoatrial junction did not differ between sham rats (52 ± 2 mmHg/μl) and CHF rats (54 ± 2 mmHg/μl). The observations support the contention that both tonic renal sympathetic renal nerve activity and suppressed renal atrial natriuretic factor responsiveness likely contribute to the blunted excretory response to VE during CHF.

Original languageEnglish (US)
Pages (from-to)H1441-H1448
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume271
Issue number4 40-4
StatePublished - Oct 1 1996

Fingerprint

Heart Failure
Kidney
Atrial Natriuretic Factor
Compliance
Myocardial Infarction

Keywords

  • atrial natriuretic factor
  • coronary artery ligation
  • diuresis
  • natriuresis
  • renal nerves

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Neural influences on renal responses to acute volume expansion in rats with heart failure. / Patel, Kaushik P; Zhang, Ping L.; Carmines, Pamela K.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 271, No. 4 40-4, 01.10.1996, p. H1441-H1448.

Research output: Contribution to journalArticle

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