Neural dynamics of verbal working memory processing in children and adolescents

Christine M. Embury, Alex I. Wiesman, Amy L. Proskovec, Mackenzie S. Mills, Elizabeth C Heinrichs-Graham, Yu Ping Wang, Vince D. Calhoun, Julia M. Stephen, Tony W Wilson

Research output: Contribution to journalArticle

Abstract

Development of cognitive functions and the underlying neurophysiology is evident throughout childhood and adolescence, with higher order processes such as working memory (WM) being some of the last cognitive faculties to fully mature. Previous functional neuroimaging studies of the neurodevelopment of WM have largely focused on overall regional activity levels rather than the temporal dynamics of neural component recruitment. In this study, we used magnetoencephalography (MEG) to examine the neural dynamics of WM in a large cohort of children and adolescents who were performing a high-load, modified verbal Sternberg WM task. Consistent with previous studies in adults, our findings indicated left-lateralized activity throughout the task period, beginning in the occipital cortices and spreading anterior to include temporal and prefrontal cortices during later encoding and into maintenance. During maintenance, the occipital alpha increase that has been widely reported in adults was found to be relatively weak in this developmental sample, suggesting continuing development of this component of neural processing, which was supported by correlational analyses. Intriguingly, we also found sex-specific developmental effects in alpha responses in the right inferior frontal region during encoding and in parietal and occipital cortices during maintenance. These findings suggested a developmental divergence between males and females in the maturation of neural circuitry serving WM during the transition from childhood to adolescence.

LanguageEnglish (US)
Pages191-197
Number of pages7
JournalNeuroImage
Volume185
DOIs
StatePublished - Jan 15 2019

Fingerprint

Short-Term Memory
Occipital Lobe
Maintenance
Magnetoencephalography
Parietal Lobe
Neurophysiology
Functional Neuroimaging
Temporal Lobe
Prefrontal Cortex
Cognition

Keywords

  • Alpha
  • Dev-CoG
  • MEG
  • Neuroimaging
  • Oscillations
  • Working memory

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Neural dynamics of verbal working memory processing in children and adolescents. / Embury, Christine M.; Wiesman, Alex I.; Proskovec, Amy L.; Mills, Mackenzie S.; Heinrichs-Graham, Elizabeth C; Wang, Yu Ping; Calhoun, Vince D.; Stephen, Julia M.; Wilson, Tony W.

In: NeuroImage, Vol. 185, 15.01.2019, p. 191-197.

Research output: Contribution to journalArticle

Embury, CM, Wiesman, AI, Proskovec, AL, Mills, MS, Heinrichs-Graham, EC, Wang, YP, Calhoun, VD, Stephen, JM & Wilson, TW 2019, 'Neural dynamics of verbal working memory processing in children and adolescents' NeuroImage, vol. 185, pp. 191-197. https://doi.org/10.1016/j.neuroimage.2018.10.038
Embury, Christine M. ; Wiesman, Alex I. ; Proskovec, Amy L. ; Mills, Mackenzie S. ; Heinrichs-Graham, Elizabeth C ; Wang, Yu Ping ; Calhoun, Vince D. ; Stephen, Julia M. ; Wilson, Tony W. / Neural dynamics of verbal working memory processing in children and adolescents. In: NeuroImage. 2019 ; Vol. 185. pp. 191-197.
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