Neural dynamics of selective attention deficits in HIV-associated neurocognitive disorder

Brandon J. Lew, Timothy J. McDermott, Alex I. Wiesman, Jennifer O'Neill, Mackenzie S. Mills, Kevin R. Robertson, Howard S Fox, Susan Swindells, Tony W Wilson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective To identify the neural markers of attention dysfunction in patients with HIV-associated neurocognitive disorder (HAND). Methods Sixty participants, including 40 HIV-infected adults (half with HAND) and 20 demographically matched controls performed a visual selective attention task while undergoing high-density magnetoencephalography. Neuronal activity related to selective attention processing was quantified and compared across the 3 groups, and correlated with neuropsychological measures of attention and executive function. Spontaneous neural activity was also extracted from these attention-related cortical areas and examined with respect to HAND status. Results HIV-infected participants with and without HAND exhibited behavioral selective attention deficits on the magnetoencephalography task, as indicated by an increased flanker effect. Neuronal measures of flanker interference activity in the alpha and theta range revealed differential dynamics in attention-related brain areas across the 3 groups, especially in those with HAND. In addition, theta range flanker interference activity in the left inferior frontal and dorsolateral prefrontal cortex was associated with executive function and attention composite scores, respectively. Progressively stronger spontaneous alpha and theta activity was also found in unimpaired HIV-infected and HAND participants relative to controls across brain regions implicated in different components of attention processing. Conclusions Behavioral and neuronal metrics of selective attention performance distinguish participants with HAND from controls and unimpaired HIV-infected participants. These metrics, along with measures of local spontaneous neural activity, may hold promise as early markers of cognitive decline in participants with HIV infection and be useful prognostic indicators for HAND.

Original languageEnglish (US)
Pages (from-to)E1860-E1869
JournalNeurology
Volume91
Issue number20
DOIs
StatePublished - Jan 1 2018

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HIV
Magnetoencephalography
Executive Function
Neurocognitive Disorders
Brain
Prefrontal Cortex
HIV Infections

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lew, B. J., McDermott, T. J., Wiesman, A. I., O'Neill, J., Mills, M. S., Robertson, K. R., ... Wilson, T. W. (2018). Neural dynamics of selective attention deficits in HIV-associated neurocognitive disorder. Neurology, 91(20), E1860-E1869. https://doi.org/10.1212/WNL.0000000000006504

Neural dynamics of selective attention deficits in HIV-associated neurocognitive disorder. / Lew, Brandon J.; McDermott, Timothy J.; Wiesman, Alex I.; O'Neill, Jennifer; Mills, Mackenzie S.; Robertson, Kevin R.; Fox, Howard S; Swindells, Susan; Wilson, Tony W.

In: Neurology, Vol. 91, No. 20, 01.01.2018, p. E1860-E1869.

Research output: Contribution to journalArticle

Lew, BJ, McDermott, TJ, Wiesman, AI, O'Neill, J, Mills, MS, Robertson, KR, Fox, HS, Swindells, S & Wilson, TW 2018, 'Neural dynamics of selective attention deficits in HIV-associated neurocognitive disorder', Neurology, vol. 91, no. 20, pp. E1860-E1869. https://doi.org/10.1212/WNL.0000000000006504
Lew BJ, McDermott TJ, Wiesman AI, O'Neill J, Mills MS, Robertson KR et al. Neural dynamics of selective attention deficits in HIV-associated neurocognitive disorder. Neurology. 2018 Jan 1;91(20):E1860-E1869. https://doi.org/10.1212/WNL.0000000000006504
Lew, Brandon J. ; McDermott, Timothy J. ; Wiesman, Alex I. ; O'Neill, Jennifer ; Mills, Mackenzie S. ; Robertson, Kevin R. ; Fox, Howard S ; Swindells, Susan ; Wilson, Tony W. / Neural dynamics of selective attention deficits in HIV-associated neurocognitive disorder. In: Neurology. 2018 ; Vol. 91, No. 20. pp. E1860-E1869.
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abstract = "Objective To identify the neural markers of attention dysfunction in patients with HIV-associated neurocognitive disorder (HAND). Methods Sixty participants, including 40 HIV-infected adults (half with HAND) and 20 demographically matched controls performed a visual selective attention task while undergoing high-density magnetoencephalography. Neuronal activity related to selective attention processing was quantified and compared across the 3 groups, and correlated with neuropsychological measures of attention and executive function. Spontaneous neural activity was also extracted from these attention-related cortical areas and examined with respect to HAND status. Results HIV-infected participants with and without HAND exhibited behavioral selective attention deficits on the magnetoencephalography task, as indicated by an increased flanker effect. Neuronal measures of flanker interference activity in the alpha and theta range revealed differential dynamics in attention-related brain areas across the 3 groups, especially in those with HAND. In addition, theta range flanker interference activity in the left inferior frontal and dorsolateral prefrontal cortex was associated with executive function and attention composite scores, respectively. Progressively stronger spontaneous alpha and theta activity was also found in unimpaired HIV-infected and HAND participants relative to controls across brain regions implicated in different components of attention processing. Conclusions Behavioral and neuronal metrics of selective attention performance distinguish participants with HAND from controls and unimpaired HIV-infected participants. These metrics, along with measures of local spontaneous neural activity, may hold promise as early markers of cognitive decline in participants with HIV infection and be useful prognostic indicators for HAND.",
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