Neural correlates of the propensity for retaliatory behavior in youths with disruptive behavior disorders

Stuart F White, Michelle Van Tieghem, Sarah J. Brislin, Isaiah Sypher, Stephen Sinclair, Daniel S. Pine, Soonjo Hwang, Robert James Blair

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: Youths with disruptive behavior disorders (DBD) (conduct disorder and oppositional defiant disorder) have an elevated risk for maladaptive reactive aggression. Theory suggests that this is due to an elevated sensitivity of basic threat circuitry implicated in retaliation (amygdala/periaqueductal gray) in youths with DBD and low levels of callous-unemotional traits and dysfunctional regulatory activity in the ventromedial prefrontal cortex in youthswith DBD irrespective of callous-unemotional traits. Method: A total of 56 youths 10-18 years of age (23 of them female) participated in the study: 30 youths with DBD, divided bymedian split into groupswith high and lowlevels of callousunemotional traits, and 26 healthy youths. All participants completed an ultimatum game task during functional MRI. Results: Relative to the other groups, youths with DBD and low levels of callous-unemotional traits showed greater increases in activation of basic threat circuitry when punishing others and dysfunctional down-regulation of the ventromedial prefrontal cortex during retaliation. Relative to healthy youths, all youths with DBD showed reduced amygdala-ventromedial prefrontal cortex connectivity during high provocation. Ventromedial prefrontal cortex responsiveness and ventromedial prefrontal cortex-amygdala connectivity were related to patients' retaliatory propensity (behavioral responses during the task) and parent-reported reactive aggression. Conclusions: These data suggest differences in the underlying neurobiology of maladaptive reactive aggression in youths with DBD who have relatively low levels of callousunemotional traits. Youths with DBD and low callousunemotional traits alone showed significantly greater threat responses during retaliation relative to comparison subjects. These data also suggest that ventromedial prefrontal cortex-amygdala connectivity is critical for regulating retaliation/reactive aggression and, when dysfunctional, contributes to reactive aggression, independent of level of callous-unemotional traits.

Original languageEnglish (US)
Pages (from-to)282-290
Number of pages9
JournalAmerican Journal of Psychiatry
Volume173
Issue number3
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

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Attention Deficit and Disruptive Behavior Disorders
Prefrontal Cortex
Aggression
Amygdala
Conduct Disorder
Periaqueductal Gray
Neurobiology
Down-Regulation
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Medicine(all)

Cite this

Neural correlates of the propensity for retaliatory behavior in youths with disruptive behavior disorders. / White, Stuart F; Van Tieghem, Michelle; Brislin, Sarah J.; Sypher, Isaiah; Sinclair, Stephen; Pine, Daniel S.; Hwang, Soonjo; Blair, Robert James.

In: American Journal of Psychiatry, Vol. 173, No. 3, 01.03.2016, p. 282-290.

Research output: Contribution to journalArticle

White, Stuart F ; Van Tieghem, Michelle ; Brislin, Sarah J. ; Sypher, Isaiah ; Sinclair, Stephen ; Pine, Daniel S. ; Hwang, Soonjo ; Blair, Robert James. / Neural correlates of the propensity for retaliatory behavior in youths with disruptive behavior disorders. In: American Journal of Psychiatry. 2016 ; Vol. 173, No. 3. pp. 282-290.
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abstract = "Objective: Youths with disruptive behavior disorders (DBD) (conduct disorder and oppositional defiant disorder) have an elevated risk for maladaptive reactive aggression. Theory suggests that this is due to an elevated sensitivity of basic threat circuitry implicated in retaliation (amygdala/periaqueductal gray) in youths with DBD and low levels of callous-unemotional traits and dysfunctional regulatory activity in the ventromedial prefrontal cortex in youthswith DBD irrespective of callous-unemotional traits. Method: A total of 56 youths 10-18 years of age (23 of them female) participated in the study: 30 youths with DBD, divided bymedian split into groupswith high and lowlevels of callousunemotional traits, and 26 healthy youths. All participants completed an ultimatum game task during functional MRI. Results: Relative to the other groups, youths with DBD and low levels of callous-unemotional traits showed greater increases in activation of basic threat circuitry when punishing others and dysfunctional down-regulation of the ventromedial prefrontal cortex during retaliation. Relative to healthy youths, all youths with DBD showed reduced amygdala-ventromedial prefrontal cortex connectivity during high provocation. Ventromedial prefrontal cortex responsiveness and ventromedial prefrontal cortex-amygdala connectivity were related to patients' retaliatory propensity (behavioral responses during the task) and parent-reported reactive aggression. Conclusions: These data suggest differences in the underlying neurobiology of maladaptive reactive aggression in youths with DBD who have relatively low levels of callousunemotional traits. Youths with DBD and low callousunemotional traits alone showed significantly greater threat responses during retaliation relative to comparison subjects. These data also suggest that ventromedial prefrontal cortex-amygdala connectivity is critical for regulating retaliation/reactive aggression and, when dysfunctional, contributes to reactive aggression, independent of level of callous-unemotional traits.",
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