Neural correlates of strategic processes underlying episodic memory in women with major depression

A15O-PET study

William E. Ottowitz, Thilo Deckersbach, Cary R Savage, Martin A. Lindquist, Darin D. Dougherty

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To evaluate the functional integrity of brain regions underlying strategic mnemonic processing in patients with major depressive disorder, the authors administered a modified version of the California Verbal Learning Test to depressed patients during presentation of lists of unrelated words and, conversely, during presentation of lists of related words with and without orientation regarding the relatedness of the words (eight healthy females, IQ=122, and eight depressed females, IQ=107). Brain function evaluated across all three conditions showed that patients with major depressive disorder revealed activation of the right anterior cingulate cortex, left ventrolateral prefrontal cortex, both hippocampi, and the left orbitofrontal cortex. Further analysis showed that patients with major depressive disorder had greater activation of the right anterior cingulate cortex during semantic organization and the right ventrolateral prefrontal cortex during strategy initiation.

Original languageEnglish (US)
Pages (from-to)218-230
Number of pages13
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume22
Issue number2
DOIs
StatePublished - Jan 1 2010

Fingerprint

Episodic Memory
Major Depressive Disorder
Prefrontal Cortex
Depression
Gyrus Cinguli
Verbal Learning
Brain
Semantics
Hippocampus

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Neural correlates of strategic processes underlying episodic memory in women with major depression : A15O-PET study. / Ottowitz, William E.; Deckersbach, Thilo; Savage, Cary R; Lindquist, Martin A.; Dougherty, Darin D.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 22, No. 2, 01.01.2010, p. 218-230.

Research output: Contribution to journalArticle

Ottowitz, William E. ; Deckersbach, Thilo ; Savage, Cary R ; Lindquist, Martin A. ; Dougherty, Darin D. / Neural correlates of strategic processes underlying episodic memory in women with major depression : A15O-PET study. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2010 ; Vol. 22, No. 2. pp. 218-230.
@article{f119d19e185d49288362d5aa563ebbdc,
title = "Neural correlates of strategic processes underlying episodic memory in women with major depression: A15O-PET study",
abstract = "To evaluate the functional integrity of brain regions underlying strategic mnemonic processing in patients with major depressive disorder, the authors administered a modified version of the California Verbal Learning Test to depressed patients during presentation of lists of unrelated words and, conversely, during presentation of lists of related words with and without orientation regarding the relatedness of the words (eight healthy females, IQ=122, and eight depressed females, IQ=107). Brain function evaluated across all three conditions showed that patients with major depressive disorder revealed activation of the right anterior cingulate cortex, left ventrolateral prefrontal cortex, both hippocampi, and the left orbitofrontal cortex. Further analysis showed that patients with major depressive disorder had greater activation of the right anterior cingulate cortex during semantic organization and the right ventrolateral prefrontal cortex during strategy initiation.",
author = "Ottowitz, {William E.} and Thilo Deckersbach and Savage, {Cary R} and Lindquist, {Martin A.} and Dougherty, {Darin D.}",
year = "2010",
month = "1",
day = "1",
doi = "10.1176/jnp.2010.22.2.218",
language = "English (US)",
volume = "22",
pages = "218--230",
journal = "Journal of Neuropsychiatry and Clinical Neurosciences",
issn = "0895-0172",
publisher = "American Psychiatric Publishing Inc.",
number = "2",

}

TY - JOUR

T1 - Neural correlates of strategic processes underlying episodic memory in women with major depression

T2 - A15O-PET study

AU - Ottowitz, William E.

AU - Deckersbach, Thilo

AU - Savage, Cary R

AU - Lindquist, Martin A.

AU - Dougherty, Darin D.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - To evaluate the functional integrity of brain regions underlying strategic mnemonic processing in patients with major depressive disorder, the authors administered a modified version of the California Verbal Learning Test to depressed patients during presentation of lists of unrelated words and, conversely, during presentation of lists of related words with and without orientation regarding the relatedness of the words (eight healthy females, IQ=122, and eight depressed females, IQ=107). Brain function evaluated across all three conditions showed that patients with major depressive disorder revealed activation of the right anterior cingulate cortex, left ventrolateral prefrontal cortex, both hippocampi, and the left orbitofrontal cortex. Further analysis showed that patients with major depressive disorder had greater activation of the right anterior cingulate cortex during semantic organization and the right ventrolateral prefrontal cortex during strategy initiation.

AB - To evaluate the functional integrity of brain regions underlying strategic mnemonic processing in patients with major depressive disorder, the authors administered a modified version of the California Verbal Learning Test to depressed patients during presentation of lists of unrelated words and, conversely, during presentation of lists of related words with and without orientation regarding the relatedness of the words (eight healthy females, IQ=122, and eight depressed females, IQ=107). Brain function evaluated across all three conditions showed that patients with major depressive disorder revealed activation of the right anterior cingulate cortex, left ventrolateral prefrontal cortex, both hippocampi, and the left orbitofrontal cortex. Further analysis showed that patients with major depressive disorder had greater activation of the right anterior cingulate cortex during semantic organization and the right ventrolateral prefrontal cortex during strategy initiation.

UR - http://www.scopus.com/inward/record.url?scp=77952359239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952359239&partnerID=8YFLogxK

U2 - 10.1176/jnp.2010.22.2.218

DO - 10.1176/jnp.2010.22.2.218

M3 - Article

VL - 22

SP - 218

EP - 230

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

SN - 0895-0172

IS - 2

ER -