Nerve growth factor receptor expression on dendritic reticulum cells in follicular lymphoid proliferations

R. Scott Strobach, Hirokazu Nakamine, Aneal S. Masih, James Linder, Dennis D. Weisenburger

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Using an antibody to the nerve growth factor receptor (NGFR), we examined dendritic reticulum cells (DRCs) immunohistochemically in 62 formalin-fixed, paraffin-embedded lymph nodes from patients with reactive follicular hyperplasia or with various types of lymphoma. A dendritic staining pattern within germinal centers was present in 25 of 26 routinely processed lymph nodes with reactive follicular hyperplasia. In contrast, dendritic staining with anti-NGFR was present within neoplastic follicles in only three of 28 follicular lymphomas. Staining of benign, residual centers with anti-NGFR was present in mantle zone lymphoma and Hodgkin's disease. These findings suggest a possible role for the NGFR in the maturation and/or activation of normal DRCs. The loss of NGFR expression in most follicular lymphomas indicates that DRCs are altered as part of the neoplastic process. The possibility that DRCs may play a role in the pathogenesis of follicular lymphoma is suggested.

Original languageEnglish (US)
Pages (from-to)481-485
Number of pages5
JournalHuman Pathology
Volume22
Issue number5
DOIs
StatePublished - May 1991

Fingerprint

Follicular Dendritic Cells
Nerve Growth Factor Receptor
Reticulum
Dendritic Cells
Follicular Lymphoma
Staining and Labeling
Hyperplasia
Lymph Nodes
Neoplastic Processes
Mantle-Cell Lymphoma
Germinal Center
Hodgkin Disease
Paraffin
Formaldehyde
Lymphoma
Antibodies

Keywords

  • dendritic reticulum cell
  • follicular hyperplasia
  • follicular lymphoma
  • nerve growth factor receptor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Nerve growth factor receptor expression on dendritic reticulum cells in follicular lymphoid proliferations. / Scott Strobach, R.; Nakamine, Hirokazu; Masih, Aneal S.; Linder, James; Weisenburger, Dennis D.

In: Human Pathology, Vol. 22, No. 5, 05.1991, p. 481-485.

Research output: Contribution to journalArticle

Scott Strobach, R. ; Nakamine, Hirokazu ; Masih, Aneal S. ; Linder, James ; Weisenburger, Dennis D. / Nerve growth factor receptor expression on dendritic reticulum cells in follicular lymphoid proliferations. In: Human Pathology. 1991 ; Vol. 22, No. 5. pp. 481-485.
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