Neovascularization and Hematopoietic Stem Cells

Jingwei Lu, Vincent J. Pompili, Hiranmoy Das

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Vasculogenesis and angiogenesis are the major forms of blood vessel formation. Angiogenesis is the process where new vessels grow from pre-existing blood vessels, and is very important in the functional recovery of pathological conditions, such as wound healing and ischemic heart diseases. The development of better animal model and imaging technologies in past decades has greatly enriched our understanding on vasculogenesis and angiogenesis processes. Hypoxia turned out to be an important driving force for angiogenesis in various ischemic conditions. It stimulates expression of many growth factors like vascular endothelial growth factor, platelet-derived growth factor, insulin-like growth factor, and fibroblast growth factor, which play critical role in induction of angiogenesis. Other cellular components like monocytes, T cells, neutrophils, and platelets also play significant role in induction and regulation of angiogenesis. Various stem/progenitor cells also being recruited to the ischemic sites play crucial role in the angiogenesis process. Pre-clinical studies showed that stem/progenitor cells with/without combination of growth factors induce neovascularization in the ischemic tissues in various animal models. In this review, we will discuss about the fundamental factors that regulate the angiogenesis process and the use of stem cells as therapeutic regime for the treatment of ischemic diseases.

Original languageEnglish (US)
Pages (from-to)235-245
Number of pages11
JournalCell Biochemistry and Biophysics
Volume67
Issue number2
DOIs
StatePublished - Jan 1 2013

Fingerprint

Hematopoietic Stem Cells
Stem cells
Stem Cells
Blood vessels
Intercellular Signaling Peptides and Proteins
Animals
T-cells
Fibroblast Growth Factors
Platelet-Derived Growth Factor
Somatomedins
Blood Vessels
Platelets
Animal Models
Vascular Endothelial Growth Factor A
Tissue
Angiogenesis Inducing Agents
Imaging techniques
Recovery
Wound Healing
Myocardial Ischemia

Keywords

  • Hematopoietic stem cells
  • Hypoxia
  • Neovascularization
  • Neutrophils
  • Notch signaling

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

Cite this

Neovascularization and Hematopoietic Stem Cells. / Lu, Jingwei; Pompili, Vincent J.; Das, Hiranmoy.

In: Cell Biochemistry and Biophysics, Vol. 67, No. 2, 01.01.2013, p. 235-245.

Research output: Contribution to journalReview article

Lu, Jingwei ; Pompili, Vincent J. ; Das, Hiranmoy. / Neovascularization and Hematopoietic Stem Cells. In: Cell Biochemistry and Biophysics. 2013 ; Vol. 67, No. 2. pp. 235-245.
@article{7e85a3c3be904c60b4ef6f6214ca2bcf,
title = "Neovascularization and Hematopoietic Stem Cells",
abstract = "Vasculogenesis and angiogenesis are the major forms of blood vessel formation. Angiogenesis is the process where new vessels grow from pre-existing blood vessels, and is very important in the functional recovery of pathological conditions, such as wound healing and ischemic heart diseases. The development of better animal model and imaging technologies in past decades has greatly enriched our understanding on vasculogenesis and angiogenesis processes. Hypoxia turned out to be an important driving force for angiogenesis in various ischemic conditions. It stimulates expression of many growth factors like vascular endothelial growth factor, platelet-derived growth factor, insulin-like growth factor, and fibroblast growth factor, which play critical role in induction of angiogenesis. Other cellular components like monocytes, T cells, neutrophils, and platelets also play significant role in induction and regulation of angiogenesis. Various stem/progenitor cells also being recruited to the ischemic sites play crucial role in the angiogenesis process. Pre-clinical studies showed that stem/progenitor cells with/without combination of growth factors induce neovascularization in the ischemic tissues in various animal models. In this review, we will discuss about the fundamental factors that regulate the angiogenesis process and the use of stem cells as therapeutic regime for the treatment of ischemic diseases.",
keywords = "Hematopoietic stem cells, Hypoxia, Neovascularization, Neutrophils, Notch signaling",
author = "Jingwei Lu and Pompili, {Vincent J.} and Hiranmoy Das",
year = "2013",
month = "1",
day = "1",
doi = "10.1007/s12013-011-9298-x",
language = "English (US)",
volume = "67",
pages = "235--245",
journal = "Cell Biochemistry and Biophysics",
issn = "1085-9195",
publisher = "Humana Press",
number = "2",

}

TY - JOUR

T1 - Neovascularization and Hematopoietic Stem Cells

AU - Lu, Jingwei

AU - Pompili, Vincent J.

AU - Das, Hiranmoy

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Vasculogenesis and angiogenesis are the major forms of blood vessel formation. Angiogenesis is the process where new vessels grow from pre-existing blood vessels, and is very important in the functional recovery of pathological conditions, such as wound healing and ischemic heart diseases. The development of better animal model and imaging technologies in past decades has greatly enriched our understanding on vasculogenesis and angiogenesis processes. Hypoxia turned out to be an important driving force for angiogenesis in various ischemic conditions. It stimulates expression of many growth factors like vascular endothelial growth factor, platelet-derived growth factor, insulin-like growth factor, and fibroblast growth factor, which play critical role in induction of angiogenesis. Other cellular components like monocytes, T cells, neutrophils, and platelets also play significant role in induction and regulation of angiogenesis. Various stem/progenitor cells also being recruited to the ischemic sites play crucial role in the angiogenesis process. Pre-clinical studies showed that stem/progenitor cells with/without combination of growth factors induce neovascularization in the ischemic tissues in various animal models. In this review, we will discuss about the fundamental factors that regulate the angiogenesis process and the use of stem cells as therapeutic regime for the treatment of ischemic diseases.

AB - Vasculogenesis and angiogenesis are the major forms of blood vessel formation. Angiogenesis is the process where new vessels grow from pre-existing blood vessels, and is very important in the functional recovery of pathological conditions, such as wound healing and ischemic heart diseases. The development of better animal model and imaging technologies in past decades has greatly enriched our understanding on vasculogenesis and angiogenesis processes. Hypoxia turned out to be an important driving force for angiogenesis in various ischemic conditions. It stimulates expression of many growth factors like vascular endothelial growth factor, platelet-derived growth factor, insulin-like growth factor, and fibroblast growth factor, which play critical role in induction of angiogenesis. Other cellular components like monocytes, T cells, neutrophils, and platelets also play significant role in induction and regulation of angiogenesis. Various stem/progenitor cells also being recruited to the ischemic sites play crucial role in the angiogenesis process. Pre-clinical studies showed that stem/progenitor cells with/without combination of growth factors induce neovascularization in the ischemic tissues in various animal models. In this review, we will discuss about the fundamental factors that regulate the angiogenesis process and the use of stem cells as therapeutic regime for the treatment of ischemic diseases.

KW - Hematopoietic stem cells

KW - Hypoxia

KW - Neovascularization

KW - Neutrophils

KW - Notch signaling

UR - http://www.scopus.com/inward/record.url?scp=84886591208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886591208&partnerID=8YFLogxK

U2 - 10.1007/s12013-011-9298-x

DO - 10.1007/s12013-011-9298-x

M3 - Review article

C2 - 22038301

AN - SCOPUS:84886591208

VL - 67

SP - 235

EP - 245

JO - Cell Biochemistry and Biophysics

JF - Cell Biochemistry and Biophysics

SN - 1085-9195

IS - 2

ER -