Neonatal Herpes Simplex Virus Infections

Swetha G. Pinninti, David W. Kimberlin

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Neonatal herpes simplex virus infections are uncommon, but because of the morbidity and mortality associated with the infection they are often considered in the differential diagnosis of ill neonates. The use of polymerase chain reaction for diagnosis of central nervous system infections and the development of safe and effective antiviral therapy has revolutionized the diagnosis and management of these infants. Initiation of long-term antiviral suppressive therapy in these infants has led to significant improvement in morbidity. This article summarizes the epidemiology of neonatal herpes simplex virus infections and discusses clinical presentation, diagnosis, management, and follow up of infants with neonatal herpes disease.

Original languageEnglish (US)
Pages (from-to)351-365
Number of pages15
JournalPediatric clinics of North America
Volume60
Issue number2
DOIs
StatePublished - Apr 1 2013

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Keywords

  • Acyclovir
  • Antiviral therapy
  • Neonatal herpes
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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