Neither dorsal root nor baroreceptor afferents are necessary for eliciting the renal responses to acute intravascular volume expansion in the primate Macaca fascicularis

J. P. Gilmore, T. V. Peterson, Irving H Zucker

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The authors determined the contribution of the dorsal roots, vagi, and sino-aortic nerves to the renal responses to acute isotonic, isooncotic intravascular volume expansion in the nonhuman primate, Macaca fascicularis. Expansion of the estimated blood volume by 15% produced a significant natriuresis and diuresis. There was no significant difference between the time to peak response for either. Neither dorsal rhizotomy (C6-T7) nor vagotomy and sino-aortic denervation had a significant effect on these responses. The authors conclude that these pathways are not necessary for eliciting the renal responses to hypervolemia in the nonhuman primate.

Original languageEnglish (US)
Pages (from-to)95-99
Number of pages5
JournalCirculation Research
Volume45
Issue number1
DOIs
StatePublished - Jan 1 1979

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Pressoreceptors
Macaca fascicularis
Spinal Nerve Roots
Primates
Rhizotomy
Kidney
Natriuresis
Vagotomy
Diuresis
Denervation
Blood Volume

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

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AU - Peterson, T. V.

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N2 - The authors determined the contribution of the dorsal roots, vagi, and sino-aortic nerves to the renal responses to acute isotonic, isooncotic intravascular volume expansion in the nonhuman primate, Macaca fascicularis. Expansion of the estimated blood volume by 15% produced a significant natriuresis and diuresis. There was no significant difference between the time to peak response for either. Neither dorsal rhizotomy (C6-T7) nor vagotomy and sino-aortic denervation had a significant effect on these responses. The authors conclude that these pathways are not necessary for eliciting the renal responses to hypervolemia in the nonhuman primate.

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