Naturally occurring antibodies for the group B streptococcal surface immunogenic protein (Sip) in pregnant women and newborn babies

Shannon D. Manning, Stephen Wood, Katherine Kasha, Denis Martin, Stéphane Rioux, Bernard Brodeur, H. Dele Davies

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Sip is a surface-exposed protein of GBS, which causes severe neonatal disease. Because Sip elicits a protective immune response in mice, we assessed whether pregnant women and newborns have Sip antibodies. Sera were collected from 644 pregnant women and 176 of their healthy newborns, and 10 newborns with GBS disease and their mothers. Using ELISA, most (99%) women and newborns (97%) had serum Sip antibodies, as did most newborns followed through 6 months. This suggests that naturally occurring Sip antibodies cross the placenta and persist into infancy, which underscores the need to study Sip further as a potential vaccine candidate.

Original languageEnglish (US)
Pages (from-to)6905-6912
Number of pages8
JournalVaccine
Volume24
Issue number47-48
DOIs
StatePublished - Nov 17 2006

Fingerprint

surface proteins
infants
pregnant women
Pregnant Women
Membrane Proteins
neonates
Newborn Infant
antibodies
Antibodies
Infant, Newborn, Diseases
infancy
placenta
blood proteins
Placenta
Blood Proteins
immune response
enzyme-linked immunosorbent assay
vaccines
Vaccines
Enzyme-Linked Immunosorbent Assay

Keywords

  • Antibodies
  • Group B Streptococcus
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Naturally occurring antibodies for the group B streptococcal surface immunogenic protein (Sip) in pregnant women and newborn babies. / Manning, Shannon D.; Wood, Stephen; Kasha, Katherine; Martin, Denis; Rioux, Stéphane; Brodeur, Bernard; Davies, H. Dele.

In: Vaccine, Vol. 24, No. 47-48, 17.11.2006, p. 6905-6912.

Research output: Contribution to journalArticle

Manning, Shannon D. ; Wood, Stephen ; Kasha, Katherine ; Martin, Denis ; Rioux, Stéphane ; Brodeur, Bernard ; Davies, H. Dele. / Naturally occurring antibodies for the group B streptococcal surface immunogenic protein (Sip) in pregnant women and newborn babies. In: Vaccine. 2006 ; Vol. 24, No. 47-48. pp. 6905-6912.
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