Natural lecithin promotes neural network complexity and activity

Shahrzad Latifi, Ali Tamayol, Rouhollah Habibey, Reza Sabzevari, Cyril Kahn, David Geny, Eftekhar Eftekharpour, Nasim Annabi, Axel Blau, Michel Linder, Elmira Arab-Tehrany

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Phospholipids in the brain cell membranes contain different polyunsaturated fatty acids (PUFAs), which are critical to nervous system function and structure. In particular, brain function critically depends on the uptake of the so-called â € essentialâ € fatty acids such as omega-3 (n-3) and omega-6 (n-6) PUFAs that cannot be readily synthesized by the human body. We extracted natural lecithin rich in various PUFAs from a marine source and transformed it into nanoliposomes. These nanoliposomes increased neurite outgrowth, network complexity and neural activity of cortical rat neurons in vitro. We also observed an upregulation of synapsin I (SYN1), which supports the positive role of lecithin in synaptogenesis, synaptic development and maturation. These findings suggest that lecithin nanoliposomes enhance neuronal development, which may have an impact on devising new lecithin delivery strategies for therapeutic applications.

Original languageEnglish (US)
Article number25777
JournalScientific reports
Volume6
DOIs
StatePublished - May 27 2016

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Lecithins
Unsaturated Fatty Acids
Synapsins
Essential Fatty Acids
Brain
Human Body
Nervous System
Phospholipids
Up-Regulation
Cell Membrane
Neurons
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Latifi, S., Tamayol, A., Habibey, R., Sabzevari, R., Kahn, C., Geny, D., ... Arab-Tehrany, E. (2016). Natural lecithin promotes neural network complexity and activity. Scientific reports, 6, [25777]. https://doi.org/10.1038/srep25777

Natural lecithin promotes neural network complexity and activity. / Latifi, Shahrzad; Tamayol, Ali; Habibey, Rouhollah; Sabzevari, Reza; Kahn, Cyril; Geny, David; Eftekharpour, Eftekhar; Annabi, Nasim; Blau, Axel; Linder, Michel; Arab-Tehrany, Elmira.

In: Scientific reports, Vol. 6, 25777, 27.05.2016.

Research output: Contribution to journalArticle

Latifi, S, Tamayol, A, Habibey, R, Sabzevari, R, Kahn, C, Geny, D, Eftekharpour, E, Annabi, N, Blau, A, Linder, M & Arab-Tehrany, E 2016, 'Natural lecithin promotes neural network complexity and activity', Scientific reports, vol. 6, 25777. https://doi.org/10.1038/srep25777
Latifi, Shahrzad ; Tamayol, Ali ; Habibey, Rouhollah ; Sabzevari, Reza ; Kahn, Cyril ; Geny, David ; Eftekharpour, Eftekhar ; Annabi, Nasim ; Blau, Axel ; Linder, Michel ; Arab-Tehrany, Elmira. / Natural lecithin promotes neural network complexity and activity. In: Scientific reports. 2016 ; Vol. 6.
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