Natural history of postterm choriocarcinoma

Kerry J Rodabaugh, Marilyn R. Bernstein, Donald P. Goldstein, Ross S. Berkowitz

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVE: To review the 32-year experience of the New England Trophoblastic Disease Center (NETDC) with choriocarcinoma occurring after a term gestation and to evaluate potential prognostic factors using the World Health Organization (WHO) prognostic score. STUDY DESIGN: The charts of 44 women who were treated for postterm choriocarcinoma at the NETDC from August 1964 to January 1996 were retrospectively reviewed. Demographic data and details of the clinical course were determined. Potential risk factors, including disease duration, pretreatment human chorionic gonadotropin (hCG) level, sites of metastases and stage, as well as data regarding the infants and previous and subsequent pregnancies, were evaluated. RESULTS: Five (11%) of the infants suffered significant complications secondary to maternal choriocarcinoma. The time interval from delivery to diagnosis, pretreatment hCG level and sites of metastatic disease were all significant risk factors in predicting outcome. All 31 patients with a WHO score ≤8 survived, and 6/13 (46%) patients with a WHO score > 8 died. CONCLUSION: Disease duration greater than four months from delivery, pretreatment hCG level > 100,000 mIU/mL, presence of liver or brain metastases, and a WHO score > 8 were all important predictors of outcome in patients with postterm choriocarcinoma.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume43
Issue number1
StatePublished - Jan 1 1998

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Choriocarcinoma
Natural History
Chorionic Gonadotropin
New England
Neoplasm Metastasis
Pregnancy
Mothers
Demography
Liver
Brain

Keywords

  • Choriocarcinoma
  • Trophoblastic tumor

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Natural history of postterm choriocarcinoma. / Rodabaugh, Kerry J; Bernstein, Marilyn R.; Goldstein, Donald P.; Berkowitz, Ross S.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 43, No. 1, 01.01.1998, p. 75-80.

Research output: Contribution to journalArticle

Rodabaugh, KJ, Bernstein, MR, Goldstein, DP & Berkowitz, RS 1998, 'Natural history of postterm choriocarcinoma', Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 43, no. 1, pp. 75-80.
Rodabaugh, Kerry J ; Bernstein, Marilyn R. ; Goldstein, Donald P. ; Berkowitz, Ross S. / Natural history of postterm choriocarcinoma. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 1998 ; Vol. 43, No. 1. pp. 75-80.
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