National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy

Leslie T. Cooper, Renu Virmani, Nora M. Chapman, Andrea Frustaci, Richard J. Rodeheffer, Madeleine W. Cunningham, Dennis M. McNamara

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Nonischemic dilated cardiomyopathy (DCM) is an uncommon cause of heart failure but has widespread importance because it is the cause of 45% of heart transplantations. Multiple experimental and clinical lines of evidence have implicated altered immunity in the pathogenesis of DCM. However, advances in the understanding of the mechanisms of altered immunity have not affected the diagnosis or treatment of DCM. In recognition of this problem, the National Institutes of Health sponsored an expert workshop with 2 aims: to review the current understanding of inflammation and immunity as they relate to DCM and to identify the most promising areas for future clinical research efforts in the field. This report summarizes the scientific opportunities, perceived needs and barriers, and workshop recommendations on research directions in DCM. The major recommendations from the members of the workshop are organized according to the following themes: cardiotropic viruses, innate and acquired immune responses, environmental factors, novel diagnostics, and novel therapeutics.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalMayo Clinic Proceedings
Volume81
Issue number2
DOIs
StatePublished - Feb 2006

Fingerprint

National Institutes of Health (U.S.)
Dilated Cardiomyopathy
Immunity
Inflammation
Education
Heart Transplantation
Research
Innate Immunity
Heart Failure
Viruses

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cooper, L. T., Virmani, R., Chapman, N. M., Frustaci, A., Rodeheffer, R. J., Cunningham, M. W., & McNamara, D. M. (2006). National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy. Mayo Clinic Proceedings, 81(2), 199-204. https://doi.org/10.4065/81.2.199

National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy. / Cooper, Leslie T.; Virmani, Renu; Chapman, Nora M.; Frustaci, Andrea; Rodeheffer, Richard J.; Cunningham, Madeleine W.; McNamara, Dennis M.

In: Mayo Clinic Proceedings, Vol. 81, No. 2, 02.2006, p. 199-204.

Research output: Contribution to journalArticle

Cooper, LT, Virmani, R, Chapman, NM, Frustaci, A, Rodeheffer, RJ, Cunningham, MW & McNamara, DM 2006, 'National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy', Mayo Clinic Proceedings, vol. 81, no. 2, pp. 199-204. https://doi.org/10.4065/81.2.199
Cooper LT, Virmani R, Chapman NM, Frustaci A, Rodeheffer RJ, Cunningham MW et al. National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy. Mayo Clinic Proceedings. 2006 Feb;81(2):199-204. https://doi.org/10.4065/81.2.199
Cooper, Leslie T. ; Virmani, Renu ; Chapman, Nora M. ; Frustaci, Andrea ; Rodeheffer, Richard J. ; Cunningham, Madeleine W. ; McNamara, Dennis M. / National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy. In: Mayo Clinic Proceedings. 2006 ; Vol. 81, No. 2. pp. 199-204.
@article{de01c0d185f74c428f625290ad50a9be,
title = "National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy",
abstract = "Nonischemic dilated cardiomyopathy (DCM) is an uncommon cause of heart failure but has widespread importance because it is the cause of 45{\%} of heart transplantations. Multiple experimental and clinical lines of evidence have implicated altered immunity in the pathogenesis of DCM. However, advances in the understanding of the mechanisms of altered immunity have not affected the diagnosis or treatment of DCM. In recognition of this problem, the National Institutes of Health sponsored an expert workshop with 2 aims: to review the current understanding of inflammation and immunity as they relate to DCM and to identify the most promising areas for future clinical research efforts in the field. This report summarizes the scientific opportunities, perceived needs and barriers, and workshop recommendations on research directions in DCM. The major recommendations from the members of the workshop are organized according to the following themes: cardiotropic viruses, innate and acquired immune responses, environmental factors, novel diagnostics, and novel therapeutics.",
author = "Cooper, {Leslie T.} and Renu Virmani and Chapman, {Nora M.} and Andrea Frustaci and Rodeheffer, {Richard J.} and Cunningham, {Madeleine W.} and McNamara, {Dennis M.}",
year = "2006",
month = "2",
doi = "10.4065/81.2.199",
language = "English (US)",
volume = "81",
pages = "199--204",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "2",

}

TY - JOUR

T1 - National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy

AU - Cooper, Leslie T.

AU - Virmani, Renu

AU - Chapman, Nora M.

AU - Frustaci, Andrea

AU - Rodeheffer, Richard J.

AU - Cunningham, Madeleine W.

AU - McNamara, Dennis M.

PY - 2006/2

Y1 - 2006/2

N2 - Nonischemic dilated cardiomyopathy (DCM) is an uncommon cause of heart failure but has widespread importance because it is the cause of 45% of heart transplantations. Multiple experimental and clinical lines of evidence have implicated altered immunity in the pathogenesis of DCM. However, advances in the understanding of the mechanisms of altered immunity have not affected the diagnosis or treatment of DCM. In recognition of this problem, the National Institutes of Health sponsored an expert workshop with 2 aims: to review the current understanding of inflammation and immunity as they relate to DCM and to identify the most promising areas for future clinical research efforts in the field. This report summarizes the scientific opportunities, perceived needs and barriers, and workshop recommendations on research directions in DCM. The major recommendations from the members of the workshop are organized according to the following themes: cardiotropic viruses, innate and acquired immune responses, environmental factors, novel diagnostics, and novel therapeutics.

AB - Nonischemic dilated cardiomyopathy (DCM) is an uncommon cause of heart failure but has widespread importance because it is the cause of 45% of heart transplantations. Multiple experimental and clinical lines of evidence have implicated altered immunity in the pathogenesis of DCM. However, advances in the understanding of the mechanisms of altered immunity have not affected the diagnosis or treatment of DCM. In recognition of this problem, the National Institutes of Health sponsored an expert workshop with 2 aims: to review the current understanding of inflammation and immunity as they relate to DCM and to identify the most promising areas for future clinical research efforts in the field. This report summarizes the scientific opportunities, perceived needs and barriers, and workshop recommendations on research directions in DCM. The major recommendations from the members of the workshop are organized according to the following themes: cardiotropic viruses, innate and acquired immune responses, environmental factors, novel diagnostics, and novel therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=32144444202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32144444202&partnerID=8YFLogxK

U2 - 10.4065/81.2.199

DO - 10.4065/81.2.199

M3 - Article

C2 - 16471075

AN - SCOPUS:32144444202

VL - 81

SP - 199

EP - 204

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 2

ER -