National cancer database report on chondrosarcoma of the head and neck

Brenton B. Koch, Lucy H. Karnell, Henry T. Huffman, Louis W. Apostolakis, Robert A. Robinson, Weining Zhen, Herman R. Menck

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Background. Management of chondrosarcoma of the head and neck is largely based on single-institution reports with small numbers accrued over several decades. Methods. The American College of Surgeons' National Cancer Data Base included 400 cases of chondrosarcoma of the head and neck diagnosed between 1985 and 1995. Chi square analyses of selected contingency tables and Wilcoxon regression analyses of selected survival stratifications were performed. Results. Histologic types included conventional (80.8%), myxoid (10.5%), and mesenchymal (8.8%). The mesenchymal and myxoid subtypes were rare among white patients (17.1%) and more common among African-American (31.8%) and Hispanic patients (44.9%). Treatment was most commonly surgery alone (59.5%) and surgery with irradiation (21.0%). Disease-specific survival was 87.2% at 5 years and 70.6% at 10 years. Worse 5-year survival was associated with higher grade (67.3%), regional or distant spread (71.0%), and the myxoid (45.0%) or mesenchymal (53.2%) subtypes. Conclusions. Chondrosarcoma of the head and neck encompasses a variety of lesions that differ substantially by demographic and tumor characteristics. Individual tumors can be classified further according to site of origin, histologic subtype, and tumor grade, which can be used to predict biologic behavior and prognosis. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish (US)
Pages (from-to)408-425
Number of pages18
JournalHead and Neck
Volume22
Issue number4
DOIs
StatePublished - Jul 1 2000

Fingerprint

Chondrosarcoma
Neck
Head
Databases
Survival
Neoplasms
Hispanic Americans
African Americans
Regression Analysis
Demography
Therapeutics

Keywords

  • Chondrosarcoma
  • Head and neck
  • National cancer data base

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Koch, B. B., Karnell, L. H., Huffman, H. T., Apostolakis, L. W., Robinson, R. A., Zhen, W., & Menck, H. R. (2000). National cancer database report on chondrosarcoma of the head and neck. Head and Neck, 22(4), 408-425. https://doi.org/10.1002/1097-0347(200007)22:4<408::AID-HED15>3.0.CO;2-H

National cancer database report on chondrosarcoma of the head and neck. / Koch, Brenton B.; Karnell, Lucy H.; Huffman, Henry T.; Apostolakis, Louis W.; Robinson, Robert A.; Zhen, Weining; Menck, Herman R.

In: Head and Neck, Vol. 22, No. 4, 01.07.2000, p. 408-425.

Research output: Contribution to journalArticle

Koch, BB, Karnell, LH, Huffman, HT, Apostolakis, LW, Robinson, RA, Zhen, W & Menck, HR 2000, 'National cancer database report on chondrosarcoma of the head and neck', Head and Neck, vol. 22, no. 4, pp. 408-425. https://doi.org/10.1002/1097-0347(200007)22:4<408::AID-HED15>3.0.CO;2-H
Koch, Brenton B. ; Karnell, Lucy H. ; Huffman, Henry T. ; Apostolakis, Louis W. ; Robinson, Robert A. ; Zhen, Weining ; Menck, Herman R. / National cancer database report on chondrosarcoma of the head and neck. In: Head and Neck. 2000 ; Vol. 22, No. 4. pp. 408-425.
@article{773dc60756594094bc364e379f5f09ee,
title = "National cancer database report on chondrosarcoma of the head and neck",
abstract = "Background. Management of chondrosarcoma of the head and neck is largely based on single-institution reports with small numbers accrued over several decades. Methods. The American College of Surgeons' National Cancer Data Base included 400 cases of chondrosarcoma of the head and neck diagnosed between 1985 and 1995. Chi square analyses of selected contingency tables and Wilcoxon regression analyses of selected survival stratifications were performed. Results. Histologic types included conventional (80.8{\%}), myxoid (10.5{\%}), and mesenchymal (8.8{\%}). The mesenchymal and myxoid subtypes were rare among white patients (17.1{\%}) and more common among African-American (31.8{\%}) and Hispanic patients (44.9{\%}). Treatment was most commonly surgery alone (59.5{\%}) and surgery with irradiation (21.0{\%}). Disease-specific survival was 87.2{\%} at 5 years and 70.6{\%} at 10 years. Worse 5-year survival was associated with higher grade (67.3{\%}), regional or distant spread (71.0{\%}), and the myxoid (45.0{\%}) or mesenchymal (53.2{\%}) subtypes. Conclusions. Chondrosarcoma of the head and neck encompasses a variety of lesions that differ substantially by demographic and tumor characteristics. Individual tumors can be classified further according to site of origin, histologic subtype, and tumor grade, which can be used to predict biologic behavior and prognosis. (C) 2000 John Wiley and Sons, Inc.",
keywords = "Chondrosarcoma, Head and neck, National cancer data base",
author = "Koch, {Brenton B.} and Karnell, {Lucy H.} and Huffman, {Henry T.} and Apostolakis, {Louis W.} and Robinson, {Robert A.} and Weining Zhen and Menck, {Herman R.}",
year = "2000",
month = "7",
day = "1",
doi = "10.1002/1097-0347(200007)22:4<408::AID-HED15>3.0.CO;2-H",
language = "English (US)",
volume = "22",
pages = "408--425",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - National cancer database report on chondrosarcoma of the head and neck

AU - Koch, Brenton B.

AU - Karnell, Lucy H.

AU - Huffman, Henry T.

AU - Apostolakis, Louis W.

AU - Robinson, Robert A.

AU - Zhen, Weining

AU - Menck, Herman R.

PY - 2000/7/1

Y1 - 2000/7/1

N2 - Background. Management of chondrosarcoma of the head and neck is largely based on single-institution reports with small numbers accrued over several decades. Methods. The American College of Surgeons' National Cancer Data Base included 400 cases of chondrosarcoma of the head and neck diagnosed between 1985 and 1995. Chi square analyses of selected contingency tables and Wilcoxon regression analyses of selected survival stratifications were performed. Results. Histologic types included conventional (80.8%), myxoid (10.5%), and mesenchymal (8.8%). The mesenchymal and myxoid subtypes were rare among white patients (17.1%) and more common among African-American (31.8%) and Hispanic patients (44.9%). Treatment was most commonly surgery alone (59.5%) and surgery with irradiation (21.0%). Disease-specific survival was 87.2% at 5 years and 70.6% at 10 years. Worse 5-year survival was associated with higher grade (67.3%), regional or distant spread (71.0%), and the myxoid (45.0%) or mesenchymal (53.2%) subtypes. Conclusions. Chondrosarcoma of the head and neck encompasses a variety of lesions that differ substantially by demographic and tumor characteristics. Individual tumors can be classified further according to site of origin, histologic subtype, and tumor grade, which can be used to predict biologic behavior and prognosis. (C) 2000 John Wiley and Sons, Inc.

AB - Background. Management of chondrosarcoma of the head and neck is largely based on single-institution reports with small numbers accrued over several decades. Methods. The American College of Surgeons' National Cancer Data Base included 400 cases of chondrosarcoma of the head and neck diagnosed between 1985 and 1995. Chi square analyses of selected contingency tables and Wilcoxon regression analyses of selected survival stratifications were performed. Results. Histologic types included conventional (80.8%), myxoid (10.5%), and mesenchymal (8.8%). The mesenchymal and myxoid subtypes were rare among white patients (17.1%) and more common among African-American (31.8%) and Hispanic patients (44.9%). Treatment was most commonly surgery alone (59.5%) and surgery with irradiation (21.0%). Disease-specific survival was 87.2% at 5 years and 70.6% at 10 years. Worse 5-year survival was associated with higher grade (67.3%), regional or distant spread (71.0%), and the myxoid (45.0%) or mesenchymal (53.2%) subtypes. Conclusions. Chondrosarcoma of the head and neck encompasses a variety of lesions that differ substantially by demographic and tumor characteristics. Individual tumors can be classified further according to site of origin, histologic subtype, and tumor grade, which can be used to predict biologic behavior and prognosis. (C) 2000 John Wiley and Sons, Inc.

KW - Chondrosarcoma

KW - Head and neck

KW - National cancer data base

UR - http://www.scopus.com/inward/record.url?scp=0034130550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034130550&partnerID=8YFLogxK

U2 - 10.1002/1097-0347(200007)22:4<408::AID-HED15>3.0.CO;2-H

DO - 10.1002/1097-0347(200007)22:4<408::AID-HED15>3.0.CO;2-H

M3 - Article

C2 - 10862026

AN - SCOPUS:0034130550

VL - 22

SP - 408

EP - 425

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 4

ER -