Abstract

Nasopharyngeal carcinoma (NPC) in pregnancy presents a therapeutic challenge due to its rarity. We report our management approaches in three such patients. A 37-year-old woman was diagnosed with stage III (T1N2M0) NPC at 18 weeks of gestation. She was treated with antepartum induction chemotherapy and postpartum chemoradiation. She delivered a healthy infant at 37 weeks and is in remission at 2 years. Two other patients (ages, 30 years and 20 years) were diagnosed with stage IVB and III NPC at 27 and 31 weeks of gestation respectively. Both the patients elected to wait until delivery and were subsequently treated with chemoradiation followed by adjuvant chemotherapy. The patients are in complete long-term remission. Thus antepartum induction chemotherapy after the first trimester followed by postpartum chemoradiation may be effective for NPC in pregnancy. This helps avoid radiation induced feto-toxicity. Patients who present in later pregnancy may delay therapy until after delivery.

Original languageEnglish (US)
Pages (from-to)126-130
Number of pages5
JournalCancer Treatment and Research Communications
Volume9
DOIs
StatePublished - Jan 1 2016

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Pregnancy
Induction Chemotherapy
Postpartum Period
First Pregnancy Trimester
Adjuvant Chemotherapy
Nasopharyngeal carcinoma
Radiation
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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title = "Nasopharyngeal carcinoma in pregnancy: A case series and literature review",
abstract = "Nasopharyngeal carcinoma (NPC) in pregnancy presents a therapeutic challenge due to its rarity. We report our management approaches in three such patients. A 37-year-old woman was diagnosed with stage III (T1N2M0) NPC at 18 weeks of gestation. She was treated with antepartum induction chemotherapy and postpartum chemoradiation. She delivered a healthy infant at 37 weeks and is in remission at 2 years. Two other patients (ages, 30 years and 20 years) were diagnosed with stage IVB and III NPC at 27 and 31 weeks of gestation respectively. Both the patients elected to wait until delivery and were subsequently treated with chemoradiation followed by adjuvant chemotherapy. The patients are in complete long-term remission. Thus antepartum induction chemotherapy after the first trimester followed by postpartum chemoradiation may be effective for NPC in pregnancy. This helps avoid radiation induced feto-toxicity. Patients who present in later pregnancy may delay therapy until after delivery.",
author = "Runa Shrestha and Bhatt, {Vijaya R} and Weining Zhen and Oleg Militsakh and Tomich, {Paul G} and Ganti, {Apar Kishor P}",
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T2 - A case series and literature review

AU - Shrestha, Runa

AU - Bhatt, Vijaya R

AU - Zhen, Weining

AU - Militsakh, Oleg

AU - Tomich, Paul G

AU - Ganti, Apar Kishor P

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N2 - Nasopharyngeal carcinoma (NPC) in pregnancy presents a therapeutic challenge due to its rarity. We report our management approaches in three such patients. A 37-year-old woman was diagnosed with stage III (T1N2M0) NPC at 18 weeks of gestation. She was treated with antepartum induction chemotherapy and postpartum chemoradiation. She delivered a healthy infant at 37 weeks and is in remission at 2 years. Two other patients (ages, 30 years and 20 years) were diagnosed with stage IVB and III NPC at 27 and 31 weeks of gestation respectively. Both the patients elected to wait until delivery and were subsequently treated with chemoradiation followed by adjuvant chemotherapy. The patients are in complete long-term remission. Thus antepartum induction chemotherapy after the first trimester followed by postpartum chemoradiation may be effective for NPC in pregnancy. This helps avoid radiation induced feto-toxicity. Patients who present in later pregnancy may delay therapy until after delivery.

AB - Nasopharyngeal carcinoma (NPC) in pregnancy presents a therapeutic challenge due to its rarity. We report our management approaches in three such patients. A 37-year-old woman was diagnosed with stage III (T1N2M0) NPC at 18 weeks of gestation. She was treated with antepartum induction chemotherapy and postpartum chemoradiation. She delivered a healthy infant at 37 weeks and is in remission at 2 years. Two other patients (ages, 30 years and 20 years) were diagnosed with stage IVB and III NPC at 27 and 31 weeks of gestation respectively. Both the patients elected to wait until delivery and were subsequently treated with chemoradiation followed by adjuvant chemotherapy. The patients are in complete long-term remission. Thus antepartum induction chemotherapy after the first trimester followed by postpartum chemoradiation may be effective for NPC in pregnancy. This helps avoid radiation induced feto-toxicity. Patients who present in later pregnancy may delay therapy until after delivery.

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