Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis

Terry L. Noah, Hugh R. Black, Pi-Wan Cheng, Robert E. Wood, Margaret W. Leigh

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

Cytokine levels in nasal and lower airways in young cystic fibrosis (CF) patients were compared with those in controls. Nasal (NLF) and bronchoalveolar (BALF) lavage fluids were obtained from children with or without CF who were undergoing bronchoscopy for clinical indications. In NLF, neither inflammatory cells nor cytokine concentrations differed between patients and controls. However, interleukin (IL)-8 levels in infected BALF from children with CF were markedly elevated compared with levels in infected and uninfected controls, even after standardization of IL-8 concentrations to bacterial counts. BALF IL-6 was modestly elevated in infected CF patients compared with uninfected but not infected controls; IL-10 did not differ among the groups. NLF and BALF IL-8 levels were not significantly correlated. Excessive airway inflammation in early CF thus appears to be confined to the lower respiratory tract, and IL-8 levels are markedly increased in children with CF compared with control children with a bacterial infection of the lower airways.

Original languageEnglish (US)
Pages (from-to)638-647
Number of pages10
JournalJournal of Infectious Diseases
Volume175
Issue number3
DOIs
StatePublished - Jan 1 1997

Fingerprint

Nasal Lavage Fluid
Bronchoalveolar Lavage Fluid
Cystic Fibrosis
Cytokines
Interleukin-8
Nose
Bacterial Load
Bronchoscopy
Bacterial Infections
Respiratory System
Interleukin-10
Interleukin-6
Inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis. / Noah, Terry L.; Black, Hugh R.; Cheng, Pi-Wan; Wood, Robert E.; Leigh, Margaret W.

In: Journal of Infectious Diseases, Vol. 175, No. 3, 01.01.1997, p. 638-647.

Research output: Contribution to journalArticle

Noah, Terry L. ; Black, Hugh R. ; Cheng, Pi-Wan ; Wood, Robert E. ; Leigh, Margaret W. / Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis. In: Journal of Infectious Diseases. 1997 ; Vol. 175, No. 3. pp. 638-647.
@article{b920363fbe5f47b3996a3c3bfeb10975,
title = "Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis",
abstract = "Cytokine levels in nasal and lower airways in young cystic fibrosis (CF) patients were compared with those in controls. Nasal (NLF) and bronchoalveolar (BALF) lavage fluids were obtained from children with or without CF who were undergoing bronchoscopy for clinical indications. In NLF, neither inflammatory cells nor cytokine concentrations differed between patients and controls. However, interleukin (IL)-8 levels in infected BALF from children with CF were markedly elevated compared with levels in infected and uninfected controls, even after standardization of IL-8 concentrations to bacterial counts. BALF IL-6 was modestly elevated in infected CF patients compared with uninfected but not infected controls; IL-10 did not differ among the groups. NLF and BALF IL-8 levels were not significantly correlated. Excessive airway inflammation in early CF thus appears to be confined to the lower respiratory tract, and IL-8 levels are markedly increased in children with CF compared with control children with a bacterial infection of the lower airways.",
author = "Noah, {Terry L.} and Black, {Hugh R.} and Pi-Wan Cheng and Wood, {Robert E.} and Leigh, {Margaret W.}",
year = "1997",
month = "1",
day = "1",
doi = "10.1093/infdis/175.3.638",
language = "English (US)",
volume = "175",
pages = "638--647",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis

AU - Noah, Terry L.

AU - Black, Hugh R.

AU - Cheng, Pi-Wan

AU - Wood, Robert E.

AU - Leigh, Margaret W.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Cytokine levels in nasal and lower airways in young cystic fibrosis (CF) patients were compared with those in controls. Nasal (NLF) and bronchoalveolar (BALF) lavage fluids were obtained from children with or without CF who were undergoing bronchoscopy for clinical indications. In NLF, neither inflammatory cells nor cytokine concentrations differed between patients and controls. However, interleukin (IL)-8 levels in infected BALF from children with CF were markedly elevated compared with levels in infected and uninfected controls, even after standardization of IL-8 concentrations to bacterial counts. BALF IL-6 was modestly elevated in infected CF patients compared with uninfected but not infected controls; IL-10 did not differ among the groups. NLF and BALF IL-8 levels were not significantly correlated. Excessive airway inflammation in early CF thus appears to be confined to the lower respiratory tract, and IL-8 levels are markedly increased in children with CF compared with control children with a bacterial infection of the lower airways.

AB - Cytokine levels in nasal and lower airways in young cystic fibrosis (CF) patients were compared with those in controls. Nasal (NLF) and bronchoalveolar (BALF) lavage fluids were obtained from children with or without CF who were undergoing bronchoscopy for clinical indications. In NLF, neither inflammatory cells nor cytokine concentrations differed between patients and controls. However, interleukin (IL)-8 levels in infected BALF from children with CF were markedly elevated compared with levels in infected and uninfected controls, even after standardization of IL-8 concentrations to bacterial counts. BALF IL-6 was modestly elevated in infected CF patients compared with uninfected but not infected controls; IL-10 did not differ among the groups. NLF and BALF IL-8 levels were not significantly correlated. Excessive airway inflammation in early CF thus appears to be confined to the lower respiratory tract, and IL-8 levels are markedly increased in children with CF compared with control children with a bacterial infection of the lower airways.

UR - http://www.scopus.com/inward/record.url?scp=0031035884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031035884&partnerID=8YFLogxK

U2 - 10.1093/infdis/175.3.638

DO - 10.1093/infdis/175.3.638

M3 - Article

VL - 175

SP - 638

EP - 647

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -