Nanosystems and targeted transport of medicinal preparations to the brain

V. P. Chekhonin, T. B. Dmitrieva, Yu A. Zhirkov, A. V. Kabanov, H. E. Gendelman

Research output: Contribution to journalReview article

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Abstract

Intense efforts in the last decades have resulted in numerous inventions to improve drug delivery to CNS. Some of them have significant potential for clinical applications. At the same time, the variety of these strategies is in itself indicative of great difficulties inherent in the transfer of therapeutic and imaging agents across the blood-brain barrier. Combination of several approaches, such as encapsulation of drugs in nanocontainers, incorporation in micellar nanostructures, the use of Pluronic "unimers" for inhibition of drug efflux in endothelial cells of brain capillaries, appears to be the most promising modality. The same refers to the methods of intracellular transport of drug suspensions developed recently. AU these achievements provide a solid basis for the further improvement of drug pharmacokinetic properties, reduction of systemic toxicity, increase of therapeutic efficacy, and earlier diagnosis of CNS pathology.

Original languageEnglish (US)
Pages (from-to)32-40
Number of pages9
JournalVestnik Rossiiskoi Akademii Meditsinskikh Nauk
Issue number2
Publication statusPublished - Apr 27 2009

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ASJC Scopus subject areas

  • Medicine(all)

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