Nanostructured Fibrous Membranes with Rose Spike-Like Architecture

Amir Nasajpour, Serena Mandla, Sindu Shree, Ebrahim Mostafavi, Roholah Sharifi, Akbar Khalilpour, Saghi Saghazadeh, Shabir Hassan, Michael J. Mitchell, Jeroen Leijten, Xu Hou, Alireza Moshaverinia, Nasim Annabi, Rainer Adelung, Yogendra Kumar Mishra, Su Ryon Shin, Ali Tamayol, Ali Khademhosseini

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities to pristine polymers. The majority of the studies have focused on the incorporation of spherical nanoparticles within the composite fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) nanoparticles into fibrous scaffolds fabricated by electrospinning. The addition of the branched particles resulted in their protrusion from fibers, mimicking the architecture of a rose stem. We demonstrated that the encapsulation of different-shape particles significantly influences the physicochemical and biological activities of the resultant composite scaffolds. In particular, the branched nanoparticles induced heterogeneous crystallization of the polymeric matrix and enhance the ultimate mechanical strain and strength. Moreover, the three-dimensional (3D) nature of the branched ZnO nanoparticles enhanced adhesion properties of the composite scaffolds to the tissues. In addition, the rose stem-like constructs offered excellent antibacterial activity, while supporting the growth of eukaryote cells.

Original languageEnglish (US)
Pages (from-to)6235-6240
Number of pages6
JournalNano Letters
Volume17
Issue number10
DOIs
StatePublished - Oct 11 2017

Fingerprint

Fibrous membranes
spikes
Nanoparticles
membranes
nanoparticles
Zinc Oxide
Composite materials
Zinc oxide
stems
Scaffolds
zinc oxides
composite materials
eukaryotes
Fibers
fiber composites
Electrospinning
Scaffolds (biology)
Crystallization
activity (biology)
Bioactivity

Keywords

  • antimicrobial
  • Branched tetrapod nanoparticles
  • electrospinning
  • nanocomposites
  • scaffolds
  • zinc oxide

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Nasajpour, A., Mandla, S., Shree, S., Mostafavi, E., Sharifi, R., Khalilpour, A., ... Khademhosseini, A. (2017). Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. Nano Letters, 17(10), 6235-6240. https://doi.org/10.1021/acs.nanolett.7b02929

Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. / Nasajpour, Amir; Mandla, Serena; Shree, Sindu; Mostafavi, Ebrahim; Sharifi, Roholah; Khalilpour, Akbar; Saghazadeh, Saghi; Hassan, Shabir; Mitchell, Michael J.; Leijten, Jeroen; Hou, Xu; Moshaverinia, Alireza; Annabi, Nasim; Adelung, Rainer; Mishra, Yogendra Kumar; Shin, Su Ryon; Tamayol, Ali; Khademhosseini, Ali.

In: Nano Letters, Vol. 17, No. 10, 11.10.2017, p. 6235-6240.

Research output: Contribution to journalArticle

Nasajpour, A, Mandla, S, Shree, S, Mostafavi, E, Sharifi, R, Khalilpour, A, Saghazadeh, S, Hassan, S, Mitchell, MJ, Leijten, J, Hou, X, Moshaverinia, A, Annabi, N, Adelung, R, Mishra, YK, Shin, SR, Tamayol, A & Khademhosseini, A 2017, 'Nanostructured Fibrous Membranes with Rose Spike-Like Architecture', Nano Letters, vol. 17, no. 10, pp. 6235-6240. https://doi.org/10.1021/acs.nanolett.7b02929
Nasajpour A, Mandla S, Shree S, Mostafavi E, Sharifi R, Khalilpour A et al. Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. Nano Letters. 2017 Oct 11;17(10):6235-6240. https://doi.org/10.1021/acs.nanolett.7b02929
Nasajpour, Amir ; Mandla, Serena ; Shree, Sindu ; Mostafavi, Ebrahim ; Sharifi, Roholah ; Khalilpour, Akbar ; Saghazadeh, Saghi ; Hassan, Shabir ; Mitchell, Michael J. ; Leijten, Jeroen ; Hou, Xu ; Moshaverinia, Alireza ; Annabi, Nasim ; Adelung, Rainer ; Mishra, Yogendra Kumar ; Shin, Su Ryon ; Tamayol, Ali ; Khademhosseini, Ali. / Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. In: Nano Letters. 2017 ; Vol. 17, No. 10. pp. 6235-6240.
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