Nanomaterials as stationary phases and supports in liquid chromatography

Sandya R. Beeram, Elliott Rodriguez, Suresh Doddavenkatanna, Zhao Li, Allegra Pekarek, Darin Peev, Kathryn Goerl, Gianfranco Trovato, Tino Hofmann, David S Hage

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The development of various nanomaterials over the last few decades has led to many applications for these materials in liquid chromatography (LC). This review will look at the types of nanomaterials that have been incorporated into LC systems and the applications that have been explored for such systems. A number of carbon-based nanomaterials and inorganic nanomaterials have been considered for use in LC, ranging from carbon nanotubes, fullerenes and nanodiamonds to metal nanoparticles and nanostructures based on silica, alumina, zirconia and titanium dioxide. Many ways have been described for incorporating these nanomaterials into LC systems. These methods have included covalent immobilization, adsorption, entrapment, and the synthesis or direct development of nanomaterials as part of a chromatographic support. Nanomaterials have been used in many types of LC. These applications have included the reversed-phase, normal-phase, ion-exchange, and affinity modes of LC, as well as related methods such as chiral separations, ion-pair chromatography and hydrophilic interaction liquid chromatography. Both small and large analytes (e.g., dyes, drugs, amino acids, peptides and proteins) have been used to evaluate possible applications for these nanomaterial-based methods. The use of nanomaterials in columns, capillaries and planar chromatography has been considered as part of these efforts. Potential advantages of nanomaterials in these applications have included their good chemical and physical stabilities, the variety of interactions many nanomaterials can have with analytes, and their unique retention properties in some separation formats.

Original languageEnglish (US)
Pages (from-to)2498-2512
Number of pages15
JournalElectrophoresis
Volume38
Issue number19
DOIs
StatePublished - Oct 1 2017

Fingerprint

Nanostructures
Liquid chromatography
Nanostructured materials
Liquid Chromatography
Chromatography
Nanodiamonds
Amino Acids, Peptides, and Proteins
Fullerenes
Ion chromatography
Metal Nanoparticles
Carbon Nanotubes
Aluminum Oxide
Metal nanoparticles
Ion Exchange
Silicon Dioxide
Hydrophobic and Hydrophilic Interactions
Immobilization
Adsorption
Ion exchange
Coloring Agents

Keywords

  • Liquid chromatography
  • Nanomaterials
  • Nanoparticles
  • Planar chromatography

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Beeram, S. R., Rodriguez, E., Doddavenkatanna, S., Li, Z., Pekarek, A., Peev, D., ... Hage, D. S. (2017). Nanomaterials as stationary phases and supports in liquid chromatography. Electrophoresis, 38(19), 2498-2512. https://doi.org/10.1002/elps.201700168

Nanomaterials as stationary phases and supports in liquid chromatography. / Beeram, Sandya R.; Rodriguez, Elliott; Doddavenkatanna, Suresh; Li, Zhao; Pekarek, Allegra; Peev, Darin; Goerl, Kathryn; Trovato, Gianfranco; Hofmann, Tino; Hage, David S.

In: Electrophoresis, Vol. 38, No. 19, 01.10.2017, p. 2498-2512.

Research output: Contribution to journalReview article

Beeram, SR, Rodriguez, E, Doddavenkatanna, S, Li, Z, Pekarek, A, Peev, D, Goerl, K, Trovato, G, Hofmann, T & Hage, DS 2017, 'Nanomaterials as stationary phases and supports in liquid chromatography', Electrophoresis, vol. 38, no. 19, pp. 2498-2512. https://doi.org/10.1002/elps.201700168
Beeram SR, Rodriguez E, Doddavenkatanna S, Li Z, Pekarek A, Peev D et al. Nanomaterials as stationary phases and supports in liquid chromatography. Electrophoresis. 2017 Oct 1;38(19):2498-2512. https://doi.org/10.1002/elps.201700168
Beeram, Sandya R. ; Rodriguez, Elliott ; Doddavenkatanna, Suresh ; Li, Zhao ; Pekarek, Allegra ; Peev, Darin ; Goerl, Kathryn ; Trovato, Gianfranco ; Hofmann, Tino ; Hage, David S. / Nanomaterials as stationary phases and supports in liquid chromatography. In: Electrophoresis. 2017 ; Vol. 38, No. 19. pp. 2498-2512.
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