Nanogels as pharmaceutical carriers: Finite networks of infinite capabilities

Alexander V. Kabanov, Serguei V. Vinogradov

Research output: Contribution to journalReview article

710 Citations (Scopus)

Abstract

Nanogels are swollen nanosized networks composed of hydrophilic or amphiphilic polymer chains. They are developed as carriers for the transport of drugs, and can be designed to spontaneously incorporate biologically active molecules through formation of salt bonds, hydrogen bonds, or hydrophobic interactions. Polyelectrolyte nanogels can readily incorporate oppositely charged low-molecular-mass drugs and biomacromolecules such as oligo- and polynucleotides (siRNA, DNA) as well as proteins. The guest molecules interact electrostatically with the ionic polymer chains of the gel and become bound within the finite nanogel. Multiple chemical functionalities can be employed in the nanogels to introduce imaging labels and to allow targeted drug delivery. The latter can be achieved, for example, with degradable or cleavable cross-links. Recent studies suggest that nanogels have a very promising future in biomedical applications.

Original languageEnglish (US)
Pages (from-to)5418-5429
Number of pages12
JournalAngewandte Chemie - International Edition
Volume48
Issue number30
DOIs
StatePublished - Jul 13 2009

Fingerprint

Drug products
Molecules
Oligonucleotides
Molecular mass
Polymers
Polyelectrolytes
Pharmaceutical Preparations
Labels
Hydrogen bonds
DNA
Gels
Salts
Proteins
Imaging techniques
Polynucleotides
Small Interfering RNA
NanoGel
Targeted drug delivery

Keywords

  • Drug delivery
  • Nanogels
  • Polyelectrolytes
  • Polymers
  • Polynucleotides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Nanogels as pharmaceutical carriers : Finite networks of infinite capabilities. / Kabanov, Alexander V.; Vinogradov, Serguei V.

In: Angewandte Chemie - International Edition, Vol. 48, No. 30, 13.07.2009, p. 5418-5429.

Research output: Contribution to journalReview article

Kabanov, Alexander V. ; Vinogradov, Serguei V. / Nanogels as pharmaceutical carriers : Finite networks of infinite capabilities. In: Angewandte Chemie - International Edition. 2009 ; Vol. 48, No. 30. pp. 5418-5429.
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