Nanocarriers for delivery of platinum anticancer drugs

Hardeep S. Oberoi, Natalia V. Nukolova, Alexander V. Kabanov, Tatiana K Bronich

Research output: Contribution to journalReview article

204 Citations (Scopus)

Abstract

Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to be in widespread clinical use especially for management of tumors of the ovary, testes, and the head and neck. However, several dose limiting toxicities associated with platinum drug use, partial anti-tumor response in most patients, development of drug resistance, tumor relapse, and many other challenges have severely limited the patient quality of life. These limitations have motivated an extensive research effort towards development of new strategies for improving platinum therapy. Nanocarrier-based delivery of platinum compounds is one such area of intense research effort beginning to provide encouraging preclinical and clinical results and may allow the development of the next generation of platinum chemotherapy. This review highlights current understanding on the pharmacology and limitations of platinum compounds in clinical use, and provides a comprehensive analysis of various platinum-polymer complexes, micelles, dendrimers, liposomes and other nanoparticles currently under investigation for delivery of platinum drugs.

Original languageEnglish (US)
Pages (from-to)1667-1685
Number of pages19
JournalAdvanced Drug Delivery Reviews
Volume65
Issue number13-14
DOIs
StatePublished - Nov 6 2013

Fingerprint

Platinum
Pharmaceutical Preparations
Platinum Compounds
Neoplasms
Dendrimers
Drug Therapy
Micelles
Research
Drug Resistance
Liposomes
Nanoparticles
Testis
Ovary
Polymers
Neck
Head
Quality of Life
Pharmacology
Recurrence

Keywords

  • Block ionomer complex
  • Dendrime
  • Drug delivery systems
  • Liposome
  • Micelle
  • Nanoparticle
  • Nanotube
  • Platinum drugs
  • Polymer conjugate

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Nanocarriers for delivery of platinum anticancer drugs. / Oberoi, Hardeep S.; Nukolova, Natalia V.; Kabanov, Alexander V.; Bronich, Tatiana K.

In: Advanced Drug Delivery Reviews, Vol. 65, No. 13-14, 06.11.2013, p. 1667-1685.

Research output: Contribution to journalReview article

Oberoi, Hardeep S. ; Nukolova, Natalia V. ; Kabanov, Alexander V. ; Bronich, Tatiana K. / Nanocarriers for delivery of platinum anticancer drugs. In: Advanced Drug Delivery Reviews. 2013 ; Vol. 65, No. 13-14. pp. 1667-1685.
@article{36099c977b1241e9ad44c63754f9efc5,
title = "Nanocarriers for delivery of platinum anticancer drugs",
abstract = "Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to be in widespread clinical use especially for management of tumors of the ovary, testes, and the head and neck. However, several dose limiting toxicities associated with platinum drug use, partial anti-tumor response in most patients, development of drug resistance, tumor relapse, and many other challenges have severely limited the patient quality of life. These limitations have motivated an extensive research effort towards development of new strategies for improving platinum therapy. Nanocarrier-based delivery of platinum compounds is one such area of intense research effort beginning to provide encouraging preclinical and clinical results and may allow the development of the next generation of platinum chemotherapy. This review highlights current understanding on the pharmacology and limitations of platinum compounds in clinical use, and provides a comprehensive analysis of various platinum-polymer complexes, micelles, dendrimers, liposomes and other nanoparticles currently under investigation for delivery of platinum drugs.",
keywords = "Block ionomer complex, Dendrime, Drug delivery systems, Liposome, Micelle, Nanoparticle, Nanotube, Platinum drugs, Polymer conjugate",
author = "Oberoi, {Hardeep S.} and Nukolova, {Natalia V.} and Kabanov, {Alexander V.} and Bronich, {Tatiana K}",
year = "2013",
month = "11",
day = "6",
doi = "10.1016/j.addr.2013.09.014",
language = "English (US)",
volume = "65",
pages = "1667--1685",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",
number = "13-14",

}

TY - JOUR

T1 - Nanocarriers for delivery of platinum anticancer drugs

AU - Oberoi, Hardeep S.

AU - Nukolova, Natalia V.

AU - Kabanov, Alexander V.

AU - Bronich, Tatiana K

PY - 2013/11/6

Y1 - 2013/11/6

N2 - Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to be in widespread clinical use especially for management of tumors of the ovary, testes, and the head and neck. However, several dose limiting toxicities associated with platinum drug use, partial anti-tumor response in most patients, development of drug resistance, tumor relapse, and many other challenges have severely limited the patient quality of life. These limitations have motivated an extensive research effort towards development of new strategies for improving platinum therapy. Nanocarrier-based delivery of platinum compounds is one such area of intense research effort beginning to provide encouraging preclinical and clinical results and may allow the development of the next generation of platinum chemotherapy. This review highlights current understanding on the pharmacology and limitations of platinum compounds in clinical use, and provides a comprehensive analysis of various platinum-polymer complexes, micelles, dendrimers, liposomes and other nanoparticles currently under investigation for delivery of platinum drugs.

AB - Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to be in widespread clinical use especially for management of tumors of the ovary, testes, and the head and neck. However, several dose limiting toxicities associated with platinum drug use, partial anti-tumor response in most patients, development of drug resistance, tumor relapse, and many other challenges have severely limited the patient quality of life. These limitations have motivated an extensive research effort towards development of new strategies for improving platinum therapy. Nanocarrier-based delivery of platinum compounds is one such area of intense research effort beginning to provide encouraging preclinical and clinical results and may allow the development of the next generation of platinum chemotherapy. This review highlights current understanding on the pharmacology and limitations of platinum compounds in clinical use, and provides a comprehensive analysis of various platinum-polymer complexes, micelles, dendrimers, liposomes and other nanoparticles currently under investigation for delivery of platinum drugs.

KW - Block ionomer complex

KW - Dendrime

KW - Drug delivery systems

KW - Liposome

KW - Micelle

KW - Nanoparticle

KW - Nanotube

KW - Platinum drugs

KW - Polymer conjugate

UR - http://www.scopus.com/inward/record.url?scp=84888199191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888199191&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2013.09.014

DO - 10.1016/j.addr.2013.09.014

M3 - Review article

C2 - 24113520

AN - SCOPUS:84888199191

VL - 65

SP - 1667

EP - 1685

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

IS - 13-14

ER -