Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling

Yonggang Ma, Lisandra E. De Castro Brás, Hiroe Toba, Rugmani Padmanabhan Iyer, Michael E. Hall, Michael D. Winniford, Richard A. Lange, Suresh C. Tyagi, Merry L. Lindsey

Research output: Contribution to journalReview article

69 Citations (Scopus)

Abstract

The cardiac extracellular matrix (ECM) fills the space between cells, supports tissue organization, and transduces mechanical, chemical, and biological signals to regulate homeostasis of the left ventricle (LV). Following myocardial infarction (MI), a multitude of ECM proteins are synthesized to replace myocyte loss and form a reparative scar. Activated fibroblasts (myofibroblasts) are the primary source of ECM proteins, thus playing a key role in cardiac repair. A balanced turnover of ECM through regulation of synthesis by myofibroblasts and degradation by matrix metalloproteinases (MMPs) is critical for proper scar formation. In this review, we summarize the current literature on the roles of myofibroblasts, MMPs, and ECM proteins in MI-induced LV remodeling. In addition, we discuss future research directions that are needed to further elucidate the molecular mechanisms of ECM actions to optimize cardiac repair.

Original languageEnglish (US)
Pages (from-to)1113-1127
Number of pages15
JournalPflugers Archiv European Journal of Physiology
Volume466
Issue number6
DOIs
StatePublished - Jun 2014

Fingerprint

Myofibroblasts
Extracellular Matrix Proteins
Extracellular Matrix
Myocardial Infarction
Matrix Metalloproteinases
Cicatrix
Repair
Ventricular Remodeling
Fibroblasts
Muscle Cells
Heart Ventricles
Homeostasis
Tissue
Degradation

Keywords

  • Extracellular matrix
  • MMP-9
  • Myocardial infarction
  • Myofibroblast
  • Proteomics
  • Review

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling. / Ma, Yonggang; De Castro Brás, Lisandra E.; Toba, Hiroe; Iyer, Rugmani Padmanabhan; Hall, Michael E.; Winniford, Michael D.; Lange, Richard A.; Tyagi, Suresh C.; Lindsey, Merry L.

In: Pflugers Archiv European Journal of Physiology, Vol. 466, No. 6, 06.2014, p. 1113-1127.

Research output: Contribution to journalReview article

Ma, Y, De Castro Brás, LE, Toba, H, Iyer, RP, Hall, ME, Winniford, MD, Lange, RA, Tyagi, SC & Lindsey, ML 2014, 'Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling', Pflugers Archiv European Journal of Physiology, vol. 466, no. 6, pp. 1113-1127. https://doi.org/10.1007/s00424-014-1463-9
Ma, Yonggang ; De Castro Brás, Lisandra E. ; Toba, Hiroe ; Iyer, Rugmani Padmanabhan ; Hall, Michael E. ; Winniford, Michael D. ; Lange, Richard A. ; Tyagi, Suresh C. ; Lindsey, Merry L. / Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling. In: Pflugers Archiv European Journal of Physiology. 2014 ; Vol. 466, No. 6. pp. 1113-1127.
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