Myocardial perfusion abnormalities during low-dose dobutamine after coronary reperfusion can be demonstrated with intravenous perfluorocarbon- exposed sonicated dextrose albumin ultrasound contrast

Thomas Richard Porter, Feng Xie, Alan Kricsfeld, Ubeydullah Deligonul, Karen Kilzer, David Kricsfeld

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Abstract

We measured background-subtracted peak myocardial videointensity (PMVI) in the left anterior descending and left circumflex perfusion zones in open- chest dogs after intravenous injection of perfluorocarbon-exposed sonicated dextrose albumin ultrasound contrast (PESDA) after reperfusion of a coronary occlusion. These measurements were repeated during low-dose dobutamine (LDD). The ratio of PMVI in the reperfused zone (RZ) compared with the adjacent normal zone (NZ) was measured at baseline and during LDD. Dogs with a >50% diameter residual stenosis were group I (n = 10), and those with <50% residual stenosis were group II (n = 13). Wall-thickening (WT) responses to LDD were not different between groups. Although the PMVI ratio (PMVI(RZ)/PMVI(Nz)) was the same in both groups at baseline, it decreased by >0.1 during LDD in 8 of 10 in group I compared with only 3 of 13 in group II dogs (p = 0.01). PMVI in the RZ increased by ≥1.5 U in 12 of 13 group II dogs during LDD, but only in 3 of 10 group I dogs. Therefore, intravenous PESDA can be combined with WT responses to define both myocardial function and flow after reperfusion.

Original languageEnglish (US)
Pages (from-to)1079-1087
Number of pages9
JournalAmerican Heart Journal
Volume131
Issue number6
DOIs
StatePublished - Jan 1 1996

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Fluorocarbons
Myocardial Reperfusion
Dobutamine
Albumins
Perfusion
Dogs
Glucose
Reperfusion
Coronary Occlusion
Intravenous Injections
Pathologic Constriction
Thorax

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Myocardial perfusion abnormalities during low-dose dobutamine after coronary reperfusion can be demonstrated with intravenous perfluorocarbon- exposed sonicated dextrose albumin ultrasound contrast. / Porter, Thomas Richard; Xie, Feng; Kricsfeld, Alan; Deligonul, Ubeydullah; Kilzer, Karen; Kricsfeld, David.

In: American Heart Journal, Vol. 131, No. 6, 01.01.1996, p. 1079-1087.

Research output: Contribution to journalArticle

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