Myocardial deformation assessed by longitudinal strain: Chamber specific normative data for CMR-feature tracking from the German competence network for congenital heart defects

Quanliang Shang, Shivani Patel, Michael Steinmetz, Andreas Schuster, David Alan Danford, Philipp Beerbaum, Samir Sarikouch, Shelby Kutty

Research output: Contribution to journalArticle

Abstract

Purpose: Left ventricular two-dimensional global longitudinal strain (LS) is superior to ejection fraction (EF) as predictor of outcome. We provide reference data for atrial and ventricular global LS during childhood and adolescence by CMR feature tracking (FT). Methods: We prospectively enrolled 115 healthy subjects (56 male, mean age 12.4 ± 4.1 years) at a single institution. CMR consisted of standard two-dimensional steady-state free-precession acquisitions. CMR-FT was performed on ventricular horizontal long-axis images for derivation of right and left atrial (RA, LA) and right and left ventricular (RV, LV) peak global LS. End-diastolic volumes (EDVs) and EF were measured. Correlations were explored for LS with age, EDV and EF of each chamber. Results: Mean±SD of LS (%) for RA, RV, LA and LV were 26.56±10.2, -17.96±5.4, 26.45±10.6 and -17.47±5, respectively. There was a positive correlation of LS in LA, LV, RA and RV with corresponding EF (all P<0.05); correlations with age were weak. Gender-wise differences were not significant for atrial and ventricular LS, strain rate and displacement. Inter- and intra-observer comparisons showed moderate agreements. Conclusions: Chamber-specific nomograms for paediatric atrial and ventricular LS are provided to serve as clinical reference, and to facilitate CMR-based deformation research. Key Points: • No normative data exist for CMR-derived global longitudinal strain in the young. • This prospective study provides reference data for atrial and ventricular longitudinal strain. • The data will serve as reference for CMR-based clinical and research use.

Original languageEnglish (US)
Pages (from-to)1257-1266
Number of pages10
JournalEuropean Radiology
Volume28
Issue number3
DOIs
StatePublished - Mar 1 2018

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Congenital Heart Defects
Mental Competency
Nomograms
Research
Healthy Volunteers
Prospective Studies
Pediatrics
Displacement (Psychology)

Keywords

  • Cardiac deformation
  • Cardiovascular magnetic resonance
  • Feature tracking
  • Paediatric cardiology
  • Strain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Myocardial deformation assessed by longitudinal strain : Chamber specific normative data for CMR-feature tracking from the German competence network for congenital heart defects. / Shang, Quanliang; Patel, Shivani; Steinmetz, Michael; Schuster, Andreas; Danford, David Alan; Beerbaum, Philipp; Sarikouch, Samir; Kutty, Shelby.

In: European Radiology, Vol. 28, No. 3, 01.03.2018, p. 1257-1266.

Research output: Contribution to journalArticle

Shang, Quanliang ; Patel, Shivani ; Steinmetz, Michael ; Schuster, Andreas ; Danford, David Alan ; Beerbaum, Philipp ; Sarikouch, Samir ; Kutty, Shelby. / Myocardial deformation assessed by longitudinal strain : Chamber specific normative data for CMR-feature tracking from the German competence network for congenital heart defects. In: European Radiology. 2018 ; Vol. 28, No. 3. pp. 1257-1266.
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abstract = "Purpose: Left ventricular two-dimensional global longitudinal strain (LS) is superior to ejection fraction (EF) as predictor of outcome. We provide reference data for atrial and ventricular global LS during childhood and adolescence by CMR feature tracking (FT). Methods: We prospectively enrolled 115 healthy subjects (56 male, mean age 12.4 ± 4.1 years) at a single institution. CMR consisted of standard two-dimensional steady-state free-precession acquisitions. CMR-FT was performed on ventricular horizontal long-axis images for derivation of right and left atrial (RA, LA) and right and left ventricular (RV, LV) peak global LS. End-diastolic volumes (EDVs) and EF were measured. Correlations were explored for LS with age, EDV and EF of each chamber. Results: Mean±SD of LS ({\%}) for RA, RV, LA and LV were 26.56±10.2, -17.96±5.4, 26.45±10.6 and -17.47±5, respectively. There was a positive correlation of LS in LA, LV, RA and RV with corresponding EF (all P<0.05); correlations with age were weak. Gender-wise differences were not significant for atrial and ventricular LS, strain rate and displacement. Inter- and intra-observer comparisons showed moderate agreements. Conclusions: Chamber-specific nomograms for paediatric atrial and ventricular LS are provided to serve as clinical reference, and to facilitate CMR-based deformation research. Key Points: • No normative data exist for CMR-derived global longitudinal strain in the young. • This prospective study provides reference data for atrial and ventricular longitudinal strain. • The data will serve as reference for CMR-based clinical and research use.",
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T2 - Chamber specific normative data for CMR-feature tracking from the German competence network for congenital heart defects

AU - Shang, Quanliang

AU - Patel, Shivani

AU - Steinmetz, Michael

AU - Schuster, Andreas

AU - Danford, David Alan

AU - Beerbaum, Philipp

AU - Sarikouch, Samir

AU - Kutty, Shelby

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N2 - Purpose: Left ventricular two-dimensional global longitudinal strain (LS) is superior to ejection fraction (EF) as predictor of outcome. We provide reference data for atrial and ventricular global LS during childhood and adolescence by CMR feature tracking (FT). Methods: We prospectively enrolled 115 healthy subjects (56 male, mean age 12.4 ± 4.1 years) at a single institution. CMR consisted of standard two-dimensional steady-state free-precession acquisitions. CMR-FT was performed on ventricular horizontal long-axis images for derivation of right and left atrial (RA, LA) and right and left ventricular (RV, LV) peak global LS. End-diastolic volumes (EDVs) and EF were measured. Correlations were explored for LS with age, EDV and EF of each chamber. Results: Mean±SD of LS (%) for RA, RV, LA and LV were 26.56±10.2, -17.96±5.4, 26.45±10.6 and -17.47±5, respectively. There was a positive correlation of LS in LA, LV, RA and RV with corresponding EF (all P<0.05); correlations with age were weak. Gender-wise differences were not significant for atrial and ventricular LS, strain rate and displacement. Inter- and intra-observer comparisons showed moderate agreements. Conclusions: Chamber-specific nomograms for paediatric atrial and ventricular LS are provided to serve as clinical reference, and to facilitate CMR-based deformation research. Key Points: • No normative data exist for CMR-derived global longitudinal strain in the young. • This prospective study provides reference data for atrial and ventricular longitudinal strain. • The data will serve as reference for CMR-based clinical and research use.

AB - Purpose: Left ventricular two-dimensional global longitudinal strain (LS) is superior to ejection fraction (EF) as predictor of outcome. We provide reference data for atrial and ventricular global LS during childhood and adolescence by CMR feature tracking (FT). Methods: We prospectively enrolled 115 healthy subjects (56 male, mean age 12.4 ± 4.1 years) at a single institution. CMR consisted of standard two-dimensional steady-state free-precession acquisitions. CMR-FT was performed on ventricular horizontal long-axis images for derivation of right and left atrial (RA, LA) and right and left ventricular (RV, LV) peak global LS. End-diastolic volumes (EDVs) and EF were measured. Correlations were explored for LS with age, EDV and EF of each chamber. Results: Mean±SD of LS (%) for RA, RV, LA and LV were 26.56±10.2, -17.96±5.4, 26.45±10.6 and -17.47±5, respectively. There was a positive correlation of LS in LA, LV, RA and RV with corresponding EF (all P<0.05); correlations with age were weak. Gender-wise differences were not significant for atrial and ventricular LS, strain rate and displacement. Inter- and intra-observer comparisons showed moderate agreements. Conclusions: Chamber-specific nomograms for paediatric atrial and ventricular LS are provided to serve as clinical reference, and to facilitate CMR-based deformation research. Key Points: • No normative data exist for CMR-derived global longitudinal strain in the young. • This prospective study provides reference data for atrial and ventricular longitudinal strain. • The data will serve as reference for CMR-based clinical and research use.

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KW - Cardiovascular magnetic resonance

KW - Feature tracking

KW - Paediatric cardiology

KW - Strain

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