Myocardial cavitational activity during continuous infusion and bolus intravenous injections of perfluorocarbon-containing microbubbles

Thomas Richard Porter, Carr Everbach, David Kricsfeld, Feng Xie

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The 20-MHz component of broadband noise from inertial cavitation within the anterior myocardium of an open-chest dog was recorded during intravenous infusions or injections of perfluorocarbon-containing microbubbles during insonation with a 1.7-MHz harmonic transducer. Intramyocardial cavitational activity was evident even at a mechanical index of 0.2, but it increased significantly as frame rate and mechanical index were increased. The amount of myocardial contrast intensity produced by the microbubbles was increased by variables that reduced cavitational activity (eg, reducing frame rate to 1 every cardiac cycle or decreasing mechanical index). At a mechanical index of 0.2, myocardial contrast could still be observed at 10-Hz frame rates. These results confirm that intramyocardial cavitational activity is present during ultrasound imaging of microbubbles; imaging techniques that reduce cavitational activity increase the magnitude of myocardial contrast.

Original languageEnglish (US)
Pages (from-to)618-625
Number of pages8
JournalJournal of the American Society of Echocardiography
Volume14
Issue number6
DOIs
StatePublished - Jan 1 2001

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Fluorocarbons
Microbubbles
Intravenous Injections
Transducers
Intravenous Infusions
Noise
Ultrasonography
Myocardium
Thorax
Dogs

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "The 20-MHz component of broadband noise from inertial cavitation within the anterior myocardium of an open-chest dog was recorded during intravenous infusions or injections of perfluorocarbon-containing microbubbles during insonation with a 1.7-MHz harmonic transducer. Intramyocardial cavitational activity was evident even at a mechanical index of 0.2, but it increased significantly as frame rate and mechanical index were increased. The amount of myocardial contrast intensity produced by the microbubbles was increased by variables that reduced cavitational activity (eg, reducing frame rate to 1 every cardiac cycle or decreasing mechanical index). At a mechanical index of 0.2, myocardial contrast could still be observed at 10-Hz frame rates. These results confirm that intramyocardial cavitational activity is present during ultrasound imaging of microbubbles; imaging techniques that reduce cavitational activity increase the magnitude of myocardial contrast.",
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