Mydriatics slow gastric emptying in preterm infants

Savithri Bonthala, John W Sparks, Kathryn H. Musgrove, Carol Lynn Berseth

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective: Preterm infants are more likely to have episodes of abdominal distention, emesis, and gastric residuals 24 hours after their first screening examination for retinopathy of prematurity (ROP) than on the day preceding the examination. Because these feeding problems reflect abnormalities in motor function, the purpose of this study was to compare antral and duodenal motor activity and gastric emptying in preterm infants before and after the instillation of mydriatics. Study design: Using a low compliance continuous perfusion manometric system, we recorded antral and duodenal fasting motor activity in 11 preterm infants before and after the instillation of mydriatics for their first screening examination for ROP. Gastric emptying was compared before and after the eye examination. Results: Although the number of antral motor contractions remained relatively constant throughout the study, duodenal motor contractions decreased nearly fourfold after the instillation of mydriatics versus that seen before (P ≤ .01). Gastric emptying was significantly delayed after the completion of the eye examination compared with that seen before the examination (P ≤ .05). Conclusion: Current doses of mydriatics inhibit duodenal motor activity and delay gastric emptying, and these gastrointestinal effects of mydriatics may underlie the feeding difficulties seen in preterm infants on the day of screening examinations for ROP.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalJournal of Pediatrics
Volume137
Issue number3
DOIs
StatePublished - Jan 1 2000

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Mydriatics
Gastric Emptying
Premature Infants
Retinopathy of Prematurity
Motor Activity
Compliance
Vomiting
Fasting
Stomach
Perfusion
Antral

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Mydriatics slow gastric emptying in preterm infants. / Bonthala, Savithri; Sparks, John W; Musgrove, Kathryn H.; Berseth, Carol Lynn.

In: Journal of Pediatrics, Vol. 137, No. 3, 01.01.2000, p. 327-330.

Research output: Contribution to journalArticle

Bonthala, S, Sparks, JW, Musgrove, KH & Berseth, CL 2000, 'Mydriatics slow gastric emptying in preterm infants', Journal of Pediatrics, vol. 137, no. 3, pp. 327-330. https://doi.org/10.1067/mpd.2000.107842
Bonthala, Savithri ; Sparks, John W ; Musgrove, Kathryn H. ; Berseth, Carol Lynn. / Mydriatics slow gastric emptying in preterm infants. In: Journal of Pediatrics. 2000 ; Vol. 137, No. 3. pp. 327-330.
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