Mydriatics decrease small intestinal motor activity and gastric empyting after routine eye exams in preterm infants

S. Bonthala, John W Sparks, K. Musgrove, C. L. Berseth

Research output: Contribution to journalArticle

Abstract

In a retrospective review, we found that about 30% of premature infants experience clinically significant feeding intolerance after screening eye exams for retinopathy of prematurity. We hypothesized that the mydriatics used for these exams are absorbed systemically and affect gastrointestinal function. We performed continuous small intestinal manometry and assessed gastric emptying by the method of George. Eight preterm infants were studied continuously for 10 hours, with a fasting-feeding cycle, instillation of a standard dose of mydriatics (Cyclomydril), eye examination, and a second fasting-feeding cycle. Measurement Units Before Mydriatrics After Mydriatics Heart Rate (Beats/min) 162 ± 2 163 ± 4 Mean Arterial BP (mmHg) 52 ± 4 46 ± 1 Duodenal Peaks (#/30 min) 101±17 23 ± 8* Duodenal Quiescence (min/hr) 15±2 25±1* % Emptied @ 40 mm % 61±10 50± 8+ % Remaining @ 2hr % 5 ± 3 8 ± 1 *p < 0.001 and + p < 0.03; both paired t test (mean ± SEM). Mydriatics profoundly impaired intestinal functions, but did not affect cardiovascular measurements. The overall decrease in duodenal motor activity after the instillation of mydriatics was reflected in a significant decrease in gastric emptying. Instillation of mydriatics has a profound effect on gastorintestinal function and feeding regimens may need to be modified on the day of the routine eye exams in preterm infants.

Original languageEnglish (US)
JournalJournal of Investigative Medicine
Volume44
Issue number1
StatePublished - Jan 1 1996

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Mydriatics
Premature Infants
Stomach
Motor Activity
Gastric Emptying
Fasting
Retinopathy of Prematurity
Units of measurement
Manometry
Screening
Heart Rate
Scanning electron microscopy

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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Mydriatics decrease small intestinal motor activity and gastric empyting after routine eye exams in preterm infants. / Bonthala, S.; Sparks, John W; Musgrove, K.; Berseth, C. L.

In: Journal of Investigative Medicine, Vol. 44, No. 1, 01.01.1996.

Research output: Contribution to journalArticle

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