Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine

N. B. Harris, Raul G Barletta

Research output: Contribution to journalReview article

428 Citations (Scopus)

Abstract

Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the etiologic agent of a severe gastroenteritis in ruminants known as Johne's disease. Economic losses to the cattle industry in the United States are staggering, reaching $1.5 billion annually. A potential pathogenic role in humans in the etiology of Crohn's disease is under investigation. In this article, we review the epidemiology, pathogenesis, diagnostics, and disease control measures of this important veterinary pathogen. We emphasize molecular genetic aspects including the description of markers used for strain identification, diagnotics, and phylogenetic analysis. Recent important advances in the development of animal models and genetic systems to study M. paratuberculosis virulence determinants are also discussed. We conclude with proposals for the applications of these models and recombinant technology to the development of diagnostic, control, and therapeutic measures.

Original languageEnglish (US)
Pages (from-to)489-512
Number of pages24
JournalClinical Microbiology Reviews
Volume14
Issue number3
DOIs
StatePublished - Jul 24 2001

Fingerprint

Paratuberculosis
Mycobacterium avium
Veterinary Medicine
Gastroenteritis
Ruminants
Crohn Disease
Virulence
Molecular Biology
Industry
Epidemiology
Animal Models
Economics
Technology

ASJC Scopus subject areas

  • Epidemiology
  • Immunology and Microbiology(all)
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine. / Harris, N. B.; Barletta, Raul G.

In: Clinical Microbiology Reviews, Vol. 14, No. 3, 24.07.2001, p. 489-512.

Research output: Contribution to journalReview article

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