Myc activates telomerase

Jing Wang, Lin Ying Xie, Susan Allan, David Beach, Gregory J. Hannon

Research output: Contribution to journalArticle

536 Citations (Scopus)

Abstract

Telomere maintenance has been proposed as an essential prerequisite to human tumor development. The telomerase enzyme is itself a marker for tumor cells, but the genetic alterations that activate the enzyme during neoplastic transformation have remained a mystery. Here, we show that Myc induces telomerase in both normal human mammary epithelial cells (HMECs) and normal human diploid fibroblasts. Myc increases expression of hEST2 (hTRT/TP2), the limiting subunit of telomerase, and both Myc and hEST2 can extend the life span of HMECs. The ability of Myc to activate telomerase may contribute to its ability to promote tumor formation.

Original languageEnglish (US)
Pages (from-to)1769-1774
Number of pages6
JournalGenes and Development
Volume12
Issue number12
DOIs
StatePublished - Jun 15 1998

Fingerprint

Telomerase
Aptitude
Breast
Epithelial Cells
Telomere
Human Development
Enzymes
Tumor Biomarkers
Diploidy
Neoplasms
Fibroblasts
Maintenance

Keywords

  • Myc
  • Telomerase
  • Tumorigenesis
  • hEST2

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Wang, J., Xie, L. Y., Allan, S., Beach, D., & Hannon, G. J. (1998). Myc activates telomerase. Genes and Development, 12(12), 1769-1774. https://doi.org/10.1101/gad.12.12.1769

Myc activates telomerase. / Wang, Jing; Xie, Lin Ying; Allan, Susan; Beach, David; Hannon, Gregory J.

In: Genes and Development, Vol. 12, No. 12, 15.06.1998, p. 1769-1774.

Research output: Contribution to journalArticle

Wang, J, Xie, LY, Allan, S, Beach, D & Hannon, GJ 1998, 'Myc activates telomerase', Genes and Development, vol. 12, no. 12, pp. 1769-1774. https://doi.org/10.1101/gad.12.12.1769
Wang J, Xie LY, Allan S, Beach D, Hannon GJ. Myc activates telomerase. Genes and Development. 1998 Jun 15;12(12):1769-1774. https://doi.org/10.1101/gad.12.12.1769
Wang, Jing ; Xie, Lin Ying ; Allan, Susan ; Beach, David ; Hannon, Gregory J. / Myc activates telomerase. In: Genes and Development. 1998 ; Vol. 12, No. 12. pp. 1769-1774.
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