Mutation pattern of human immunodeficiency virus genes

Etsuko N. Moriyama, Yasuo Ina, Kazuho Ikeo, Nobuaki Shimizu, Takashi Gojobori

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Human immunodeficiency viruses (HIVs) show extensive genetic variation. This feature is the fundamental cause of pathogenicity of HIVs and thwarts efforts to develop effective vaccines. To understand the mutation mechanism of these viruses, we analyzed nucleotide sequences of env and gag genes of the viruses by use of molecular evolutionary methods and estimated the direction and frequency of nucleotide substitutions. Results obtained showed that the frequency of changes between A and G was extremely high and the mutation pattern of HIVs was distinct from those of nuclear genes of their host cells. This distinction may be caused by the characteristics of the reverse transcription of HIVs. The mutation pattern obtained would be helpful to construct effective antiviral drugs.

Original languageEnglish (US)
Pages (from-to)360-363
Number of pages4
JournalJournal of Molecular Evolution
Volume32
Issue number5
DOIs
StatePublished - May 1 1991

Fingerprint

Human immunodeficiency virus
human immunodeficiency virus
Viruses
mutation
Genes
HIV
Mutation
gene
virus
genes
gag Genes
antiviral agents
env Genes
viruses
reverse transcription
vaccine
pathogenicity
Nucleotides
Reverse Transcription
Antiviral Agents

Keywords

  • Antiviral drugs
  • Genetic variation
  • Human immunodeficiency viruses
  • Molecular evolution
  • Mutation pattern

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

Mutation pattern of human immunodeficiency virus genes. / Moriyama, Etsuko N.; Ina, Yasuo; Ikeo, Kazuho; Shimizu, Nobuaki; Gojobori, Takashi.

In: Journal of Molecular Evolution, Vol. 32, No. 5, 01.05.1991, p. 360-363.

Research output: Contribution to journalArticle

Moriyama, Etsuko N. ; Ina, Yasuo ; Ikeo, Kazuho ; Shimizu, Nobuaki ; Gojobori, Takashi. / Mutation pattern of human immunodeficiency virus genes. In: Journal of Molecular Evolution. 1991 ; Vol. 32, No. 5. pp. 360-363.
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