Murine cell-mediated immune response recognizes an enterovirus group-specific antigen(s)

M. A. Beck, Steven M Tracy

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Solenocytes taken from mice inoculated with coxsackievirus B3 (CVB3) (Nancy) developed an in vitro proliferative response against CVB3 antigen. This response could not be detected earlier than 8 days postinoculation but could be detected up to 28 days after exposure to CB3. CVB3-sensitized splenocytes responded not only to the CVB3 antigen but to other enteroviruses as well. This response was found to be enterovirus specific in that no response was detected to a non-enteroviral picornavirus, encephalomyocarditis virus, or to an unrelated influenza virus. The generation of a splenocyte population capable of responding to an enterovirus group antigen(s) was not limited to inoculation of mice with CVB3, as similar responses were generated when mice were inoculated with CVB2. Cell subset depletions revealed that the major cell type responding to the enterovirus group antigen(s) was the CD4+ T cell. Current evidence suggests that the group antigen(s) resides in the structural proteins of the virus, since spleen cells from mice inoculated with a UV-inactivated, highly purified preparation of CVB3 virions also responded in vitro against enteroviral antigens.

Original languageEnglish (US)
Pages (from-to)4148-4156
Number of pages9
JournalJournal of virology
Volume63
Issue number10
StatePublished - Jan 1 1989

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Enterovirus
cell-mediated immunity
antigens
Antigens
mice
splenocytes
Encephalomyocarditis virus
Picornaviridae
Viral Structural Proteins
structural proteins
Orthomyxoviridae
virion
Virion
Spleen
T-lymphocytes
cells
T-Lymphocytes
viruses

ASJC Scopus subject areas

  • Immunology

Cite this

Murine cell-mediated immune response recognizes an enterovirus group-specific antigen(s). / Beck, M. A.; Tracy, Steven M.

In: Journal of virology, Vol. 63, No. 10, 01.01.1989, p. 4148-4156.

Research output: Contribution to journalArticle

Beck, M. A. ; Tracy, Steven M. / Murine cell-mediated immune response recognizes an enterovirus group-specific antigen(s). In: Journal of virology. 1989 ; Vol. 63, No. 10. pp. 4148-4156.
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