Multisubunit receptors in the immune system and their association with the cytoskeleton: In search of functional significance

Steve Caplan, Michal Baniyash

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Various multisubunit receptors of the immune system share similarities in structure and induce closely related signal transduction pathways upon ligand binding. Examples include the T cell antigen receptor (TCR), the B cell antigen receptor (BCR), and the high-affinity receptor for immunoglobulin E (FcεRI). Although these receptors are devoid of intrinsic kinase activity, they can associate with a similar array of intracellular kinases, phosphatases and other signaling molecules. Furthermore, these receptor complexes all form an association with the cytoskeletal matrix. In this review, we compare the structural and functional characteristics of the TCR, BCR and FcεRI. We examine the role of the cytoskeleton in regulating receptor-mediated signal transduction, as analyzed in other well-characterized receptors, including the epidermal growth factor receptor and integrin receptors. On the basis of this evidence, we review the current data depicting a cytoskeletal association for multisubunit immune system receptors and explore the potential bearing of this interaction on signaling function.

Original languageEnglish (US)
Pages (from-to)98-118
Number of pages21
JournalImmunologic Research
Volume14
Issue number2
DOIs
StatePublished - Jun 1 1995

Fingerprint

B-Cell Antigen Receptors
T-Cell Antigen Receptor
Cytoskeleton
Immune System
Signal Transduction
Phosphotransferases
IgE Receptors
Phosphoric Monoester Hydrolases
Epidermal Growth Factor Receptor
Integrins
Ligands

Keywords

  • B cell antigen receptor
  • Cytoskeleton
  • Epidermal growth factor receptor
  • Fcε receptor
  • Integrin receptor
  • Signal transduction
  • T cell activation
  • T cell antigen receptor

ASJC Scopus subject areas

  • Immunology

Cite this

Multisubunit receptors in the immune system and their association with the cytoskeleton : In search of functional significance. / Caplan, Steve; Baniyash, Michal.

In: Immunologic Research, Vol. 14, No. 2, 01.06.1995, p. 98-118.

Research output: Contribution to journalArticle

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