Multistage carcinogenesis in the urinary bladder

Samuel Monroe Cohen, L. B. Ellwein

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The induction of cancer of the urinary bladder is a multi-stage process involving multiple exogenous and endogenous factors. Based on the classical initiation-promotion model, we have used N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) as initiator and sodium saccharin (SAC) or tryptophan as promoters. These latter chemicals have the properties expected of promoters: induction of hyperplasia, reversibility and nonmutagenicity. Also, tumors were induced whether the promoter was administered immediately after FANFT or beginning 6 weeks after FANFT was discontinued, but no tumors resulted if either promoterwas given without initiation with FANFT. Factor(s) present in normal urine also are involved in the promotion process, in addition to the role of urine as a carrier of carcinogens. However, administration of SAC to animals with a rapidly proliferating bladder mucosa, induced by ulceration, pellet insertion, or in utero, resulted in bladder tumor induction, even without prior initiation with FANFT. To better understand the complex interaction of the multiple variables in bladder carcinogenesis, a stochastic computer model has been formulated based on long-term carcinogenicity and tissue kinetic studies in vivo. This model indicates the importance of cell proliferation and the development of hyperplasia in carcinogenesis.

Original languageEnglish (US)
Pages (from-to)209-215
Number of pages7
JournalEnvironmental Health Perspectives
VolumeVol. 49
StatePublished - Jan 1 1983

Fingerprint

FANFT
tumor
Carcinogenesis
Urinary Bladder
urine
Tumors
Saccharin
Urinary Bladder Neoplasms
Hyperplasia
carcinogen
Urine
cancer
sodium
Cell proliferation
kinetics
Tryptophan
animal
Carcinogens
Computer Simulation
Neoplasms

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Multistage carcinogenesis in the urinary bladder. / Cohen, Samuel Monroe; Ellwein, L. B.

In: Environmental Health Perspectives, Vol. Vol. 49, 01.01.1983, p. 209-215.

Research output: Contribution to journalArticle

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