Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

Li Kuo Su, Kenneth W. Kinzler, Bert Vogelstein, Antoinette C. Preisinger, Amy Rapaich Moser, Cindy Luongo, Karen A. Gould, William F. Dove

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Abstract

Germ-line mutations of the APC gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominantly inherited disease in humans. Patients with FAP develop multiple benign colorectal tumors. Recently, a mouse lineage that exhibits an autosomal dominantly inherited predisposition to multiple intestinal neoplasia (Min) was described. Linkage analysis showed that the murine homolog of the APC gene (mApc) was tightly linked to the Min locus. Sequence comparison of mApc between normal and Min-affected mice identified a nonsense mutation, which cosegregated with the Min phenotype. This mutation is analogous to those found in FAP kindreds and in sporadic colorectal cancers.

Original languageEnglish (US)
Pages (from-to)668-670
Number of pages3
JournalScience
Volume256
Issue number5057
DOIs
StatePublished - Jan 1 1992

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APC Genes
Adenomatous Polyposis Coli
Mutation
Colorectal Neoplasms
Neoplasms
Germ-Line Mutation
Nonsense Codon
Phenotype

ASJC Scopus subject areas

  • General

Cite this

Su, L. K., Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., ... Dove, W. F. (1992). Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science, 256(5057), 668-670. https://doi.org/10.1126/science.1350108

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. / Su, Li Kuo; Kinzler, Kenneth W.; Vogelstein, Bert; Preisinger, Antoinette C.; Moser, Amy Rapaich; Luongo, Cindy; Gould, Karen A.; Dove, William F.

In: Science, Vol. 256, No. 5057, 01.01.1992, p. 668-670.

Research output: Contribution to journalArticle

Su, LK, Kinzler, KW, Vogelstein, B, Preisinger, AC, Moser, AR, Luongo, C, Gould, KA & Dove, WF 1992, 'Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene', Science, vol. 256, no. 5057, pp. 668-670. https://doi.org/10.1126/science.1350108
Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science. 1992 Jan 1;256(5057):668-670. https://doi.org/10.1126/science.1350108
Su, Li Kuo ; Kinzler, Kenneth W. ; Vogelstein, Bert ; Preisinger, Antoinette C. ; Moser, Amy Rapaich ; Luongo, Cindy ; Gould, Karen A. ; Dove, William F. / Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. In: Science. 1992 ; Vol. 256, No. 5057. pp. 668-670.
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