Multiple gastrointestinal stromal tumors and lipomatosis

Xiuli Liu, Charles Melbern Wilcox, Laurentia Nodit, Audrey J Lazenby

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this report, we describe a 36-year-old man with the synchronous occurrence of multiple gastric gastrointestinal stromal tumors and multiple intestinal lipomas. Multiple, small, and well-circumscribed gastric gastrointestinal stromal tumors (3 mm to 2 cm) were present within the gastrectomy specimen. The gastrointestinal stromal tumors were composed of epithelioid cells that were strongly positive for CD117 but negative for S100 protein or smooth muscle-specific actin. Also, 17 small submucosal lipomas were identified in the duodenal portion of the gastrectomy specimen. Endoscopic follow-up of the patient revealed more than 20 additional lipomas scattered throughout the intestine. Several large intestinal lipomas were resected endoscopically and histologically confirmed. Although both multicentric gastrointestinal stromal tumor and gastrointestinal lipomatosis have been reported in association with a few genetic syndromes, there has been no report, to our knowledge, of their coexistence. We feel that the coexistence of multiple lesions of these 2 rare diseases in this relatively young patient may represent a novel syndrome.

Original languageEnglish (US)
Pages (from-to)1825-1829
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume132
Issue number11
DOIs
StatePublished - Nov 1 2008

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Lipomatosis
Gastrointestinal Stromal Tumors
Lipoma
Gastrectomy
Stomach
Epithelioid Cells
S100 Proteins
Rare Diseases
Intestines
Smooth Muscle
Actins

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Multiple gastrointestinal stromal tumors and lipomatosis. / Liu, Xiuli; Wilcox, Charles Melbern; Nodit, Laurentia; Lazenby, Audrey J.

In: Archives of Pathology and Laboratory Medicine, Vol. 132, No. 11, 01.11.2008, p. 1825-1829.

Research output: Contribution to journalArticle

Liu, Xiuli ; Wilcox, Charles Melbern ; Nodit, Laurentia ; Lazenby, Audrey J. / Multiple gastrointestinal stromal tumors and lipomatosis. In: Archives of Pathology and Laboratory Medicine. 2008 ; Vol. 132, No. 11. pp. 1825-1829.
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