Abstract
Multinodular and vacuolating neuronal tumor is a recently described seizure-associated entity with overlapping features of a malformative and neoplastic process. We report a case of multinodular and vacuolating neuronal tumor in a 29-year-old man with a history of recent headaches and complex partial seizures. Neuroimaging revealed a nonenhancing, T2 and T2 fluid-attenuated inversion recovery hyperintense multinodular lesion in the right temporal lobe. Lesional tissue demonstrated well-demarcated nodules of ganglioid cells with vacuolation of both the perikarya and the fibrillary neuropil-like background. The ganglioid cells showed weak cytoplasmic reactivity for synaptophysin and were nonreactive for neurofilament and chromogranin. CD34-positive stellate cells were present within the nodules. A 50-gene next-generation sequencing panel did not identify any somatic mutations in genomic DNA extracted from the tumor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1005-1010 |
| Number of pages | 6 |
| Journal | American Journal of Surgical Pathology |
| Volume | 41 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jan 1 2017 |
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Keywords
- multinodular
- neuronal tumor
- seizure
ASJC Scopus subject areas
- Anatomy
- Surgery
- Pathology and Forensic Medicine
Cite this
Multinodular and Vacuolating Neuronal Tumor. / Cathcart, Sahara J.; Klug, Jeffrey R.; Helvey, Jason T.; White, Matthew L; Gard, Andrew P.; McComb, Rodney D.
In: American Journal of Surgical Pathology, Vol. 41, No. 7, 01.01.2017, p. 1005-1010.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multinodular and Vacuolating Neuronal Tumor
AU - Cathcart, Sahara J.
AU - Klug, Jeffrey R.
AU - Helvey, Jason T.
AU - White, Matthew L
AU - Gard, Andrew P.
AU - McComb, Rodney D
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Multinodular and vacuolating neuronal tumor is a recently described seizure-associated entity with overlapping features of a malformative and neoplastic process. We report a case of multinodular and vacuolating neuronal tumor in a 29-year-old man with a history of recent headaches and complex partial seizures. Neuroimaging revealed a nonenhancing, T2 and T2 fluid-attenuated inversion recovery hyperintense multinodular lesion in the right temporal lobe. Lesional tissue demonstrated well-demarcated nodules of ganglioid cells with vacuolation of both the perikarya and the fibrillary neuropil-like background. The ganglioid cells showed weak cytoplasmic reactivity for synaptophysin and were nonreactive for neurofilament and chromogranin. CD34-positive stellate cells were present within the nodules. A 50-gene next-generation sequencing panel did not identify any somatic mutations in genomic DNA extracted from the tumor.
AB - Multinodular and vacuolating neuronal tumor is a recently described seizure-associated entity with overlapping features of a malformative and neoplastic process. We report a case of multinodular and vacuolating neuronal tumor in a 29-year-old man with a history of recent headaches and complex partial seizures. Neuroimaging revealed a nonenhancing, T2 and T2 fluid-attenuated inversion recovery hyperintense multinodular lesion in the right temporal lobe. Lesional tissue demonstrated well-demarcated nodules of ganglioid cells with vacuolation of both the perikarya and the fibrillary neuropil-like background. The ganglioid cells showed weak cytoplasmic reactivity for synaptophysin and were nonreactive for neurofilament and chromogranin. CD34-positive stellate cells were present within the nodules. A 50-gene next-generation sequencing panel did not identify any somatic mutations in genomic DNA extracted from the tumor.
KW - multinodular
KW - neuronal tumor
KW - seizure
UR - http://www.scopus.com/inward/record.url?scp=85020706059&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020706059&partnerID=8YFLogxK
U2 - 10.1097/PAS.0000000000000868
DO - 10.1097/PAS.0000000000000868
M3 - Article
C2 - 28505008
AN - SCOPUS:85020706059
VL - 41
SP - 1005
EP - 1010
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
SN - 0147-5185
IS - 7
ER -