Multinodular and Vacuolating Neuronal Tumor

Sahara J. Cathcart, Jeffrey R. Klug, Jason T. Helvey, Matthew L White, Andrew P. Gard, Rodney D McComb

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Multinodular and vacuolating neuronal tumor is a recently described seizure-associated entity with overlapping features of a malformative and neoplastic process. We report a case of multinodular and vacuolating neuronal tumor in a 29-year-old man with a history of recent headaches and complex partial seizures. Neuroimaging revealed a nonenhancing, T2 and T2 fluid-attenuated inversion recovery hyperintense multinodular lesion in the right temporal lobe. Lesional tissue demonstrated well-demarcated nodules of ganglioid cells with vacuolation of both the perikarya and the fibrillary neuropil-like background. The ganglioid cells showed weak cytoplasmic reactivity for synaptophysin and were nonreactive for neurofilament and chromogranin. CD34-positive stellate cells were present within the nodules. A 50-gene next-generation sequencing panel did not identify any somatic mutations in genomic DNA extracted from the tumor.

Original languageEnglish (US)
Pages (from-to)1005-1010
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume41
Issue number7
DOIs
StatePublished - Jan 1 2017

Fingerprint

Seizures
Chromogranins
Neoplastic Processes
Neoplasms
Synaptophysin
Neuropil
Intermediate Filaments
Temporal Lobe
Neuroimaging
Headache
Mutation
DNA
Genes

Keywords

  • multinodular
  • neuronal tumor
  • seizure

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Multinodular and Vacuolating Neuronal Tumor. / Cathcart, Sahara J.; Klug, Jeffrey R.; Helvey, Jason T.; White, Matthew L; Gard, Andrew P.; McComb, Rodney D.

In: American Journal of Surgical Pathology, Vol. 41, No. 7, 01.01.2017, p. 1005-1010.

Research output: Contribution to journalArticle

Cathcart, Sahara J. ; Klug, Jeffrey R. ; Helvey, Jason T. ; White, Matthew L ; Gard, Andrew P. ; McComb, Rodney D. / Multinodular and Vacuolating Neuronal Tumor. In: American Journal of Surgical Pathology. 2017 ; Vol. 41, No. 7. pp. 1005-1010.
@article{95a04f5f18844d20be4cc0669bc00cba,
title = "Multinodular and Vacuolating Neuronal Tumor",
abstract = "Multinodular and vacuolating neuronal tumor is a recently described seizure-associated entity with overlapping features of a malformative and neoplastic process. We report a case of multinodular and vacuolating neuronal tumor in a 29-year-old man with a history of recent headaches and complex partial seizures. Neuroimaging revealed a nonenhancing, T2 and T2 fluid-attenuated inversion recovery hyperintense multinodular lesion in the right temporal lobe. Lesional tissue demonstrated well-demarcated nodules of ganglioid cells with vacuolation of both the perikarya and the fibrillary neuropil-like background. The ganglioid cells showed weak cytoplasmic reactivity for synaptophysin and were nonreactive for neurofilament and chromogranin. CD34-positive stellate cells were present within the nodules. A 50-gene next-generation sequencing panel did not identify any somatic mutations in genomic DNA extracted from the tumor.",
keywords = "multinodular, neuronal tumor, seizure",
author = "Cathcart, {Sahara J.} and Klug, {Jeffrey R.} and Helvey, {Jason T.} and White, {Matthew L} and Gard, {Andrew P.} and McComb, {Rodney D}",
year = "2017",
month = "1",
day = "1",
doi = "10.1097/PAS.0000000000000868",
language = "English (US)",
volume = "41",
pages = "1005--1010",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Multinodular and Vacuolating Neuronal Tumor

AU - Cathcart, Sahara J.

AU - Klug, Jeffrey R.

AU - Helvey, Jason T.

AU - White, Matthew L

AU - Gard, Andrew P.

AU - McComb, Rodney D

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Multinodular and vacuolating neuronal tumor is a recently described seizure-associated entity with overlapping features of a malformative and neoplastic process. We report a case of multinodular and vacuolating neuronal tumor in a 29-year-old man with a history of recent headaches and complex partial seizures. Neuroimaging revealed a nonenhancing, T2 and T2 fluid-attenuated inversion recovery hyperintense multinodular lesion in the right temporal lobe. Lesional tissue demonstrated well-demarcated nodules of ganglioid cells with vacuolation of both the perikarya and the fibrillary neuropil-like background. The ganglioid cells showed weak cytoplasmic reactivity for synaptophysin and were nonreactive for neurofilament and chromogranin. CD34-positive stellate cells were present within the nodules. A 50-gene next-generation sequencing panel did not identify any somatic mutations in genomic DNA extracted from the tumor.

AB - Multinodular and vacuolating neuronal tumor is a recently described seizure-associated entity with overlapping features of a malformative and neoplastic process. We report a case of multinodular and vacuolating neuronal tumor in a 29-year-old man with a history of recent headaches and complex partial seizures. Neuroimaging revealed a nonenhancing, T2 and T2 fluid-attenuated inversion recovery hyperintense multinodular lesion in the right temporal lobe. Lesional tissue demonstrated well-demarcated nodules of ganglioid cells with vacuolation of both the perikarya and the fibrillary neuropil-like background. The ganglioid cells showed weak cytoplasmic reactivity for synaptophysin and were nonreactive for neurofilament and chromogranin. CD34-positive stellate cells were present within the nodules. A 50-gene next-generation sequencing panel did not identify any somatic mutations in genomic DNA extracted from the tumor.

KW - multinodular

KW - neuronal tumor

KW - seizure

UR - http://www.scopus.com/inward/record.url?scp=85020706059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020706059&partnerID=8YFLogxK

U2 - 10.1097/PAS.0000000000000868

DO - 10.1097/PAS.0000000000000868

M3 - Article

C2 - 28505008

AN - SCOPUS:85020706059

VL - 41

SP - 1005

EP - 1010

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 7

ER -