Multifocal Subacute Necrotizing Encephalomyelopathy in Simmental Calves

D. J. Steffen, J. G. Vestweber, W. Cash, M. el-Hamidi, H. W. Leipold

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In 24 cases of multifocal necrotizing encephalopathy (MNE) in Simmental and Simmental-cross cattle, clinical features varied, consisting of mild rear limb ataxia, caudal paresis, and, less often, sudden death. Bilateral and symmetric malacic lesions were present in the brain stem (olivary nucleus) of all affected calves. Foci of malacia affecting thoracic spinal cord and additional brain stem sites were common. Neuronal cell bodies and hypertrophied capillaries were present within malacic foci. Rarefaction of neuropil, progressing to complete parenchymal loss, characterized advanced lesions. Pathologic features were similar to those of Leigh syndrome in humans, and a similar defect in aerobic metabolism is hypothesized. Occurrence of the syndrome within 1 breed over a wide geographic area suggests that hereditary factors contribute to development of MNE.

Original languageEnglish (US)
Pages (from-to)466-472
Number of pages7
JournalJournal of Veterinary Diagnostic Investigation
Volume6
Issue number4
DOIs
StatePublished - Oct 1994

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myeloencephalopathy
Leigh Disease
encephalopathy
Simmental
Brain Diseases
brain stem
lesions (animal)
Brain Stem
Olivary Nucleus
calves
paresis
Neuropil
Paresis
chest
Ataxia
Sudden Death
limbs (animal)
spinal cord
Spinal Cord
Thorax

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Multifocal Subacute Necrotizing Encephalomyelopathy in Simmental Calves. / Steffen, D. J.; Vestweber, J. G.; Cash, W.; el-Hamidi, M.; Leipold, H. W.

In: Journal of Veterinary Diagnostic Investigation, Vol. 6, No. 4, 10.1994, p. 466-472.

Research output: Contribution to journalArticle

Steffen, D. J. ; Vestweber, J. G. ; Cash, W. ; el-Hamidi, M. ; Leipold, H. W. / Multifocal Subacute Necrotizing Encephalomyelopathy in Simmental Calves. In: Journal of Veterinary Diagnostic Investigation. 1994 ; Vol. 6, No. 4. pp. 466-472.
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