Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis

Ponnada A. Narayana, Jerry S. Wolinsky, Balasrinivasa R Sajja, Renjie He, Meghana Mehta, William Books, Corey Ford, Todd Richards, James Bowen, J. William Lindsey, Yvan Boulanger, Pierre Duquette, Douglas L. Arnold

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Multicentre baseline proton magnetic resonance spectroscopic data on primary progressive multiple sclerosis (PPMS) patients are acquired and analysed, using automatic analysis software. The metabolite ratios did not differ from centre to centre. The average N-acetylaspartate/creatine (NAA/Cr) ratio in PPMS was significantly lower compared to normal controls. No significant differences were observed in this ratio between lesion-containing regions (LCR) and normal-appearing tissues (NAT). Strong lipid resonances, even in the absence of lesions, are observed in the both grey and white matter in these patients. These observations suggest extensive diffuse and/or microscopic pathology in PPMS. No significant correlation between any of the metabolite ratios and the Extended Disability Scale Score (EDSS) or with other MR measures such as lesion burden and enhancement volumes is observed.

Original languageEnglish (US)
JournalMultiple Sclerosis
Volume10
Issue numberSUPPL. 1
StatePublished - Jun 1 2004

Fingerprint

Chronic Progressive Multiple Sclerosis
Magnetic Resonance Imaging
Creatine
Protons
Magnetic Resonance Spectroscopy
Software
Pathology
Lipids
Proton Magnetic Resonance Spectroscopy

Keywords

  • MRI
  • N-acetylaspartate
  • Primary progressive multiple sclerosis
  • Proton spectroscopic imaging

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Narayana, P. A., Wolinsky, J. S., Sajja, B. R., He, R., Mehta, M., Books, W., ... Arnold, D. L. (2004). Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis. Multiple Sclerosis, 10(SUPPL. 1).

Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis. / Narayana, Ponnada A.; Wolinsky, Jerry S.; Sajja, Balasrinivasa R; He, Renjie; Mehta, Meghana; Books, William; Ford, Corey; Richards, Todd; Bowen, James; William Lindsey, J.; Boulanger, Yvan; Duquette, Pierre; Arnold, Douglas L.

In: Multiple Sclerosis, Vol. 10, No. SUPPL. 1, 01.06.2004.

Research output: Contribution to journalArticle

Narayana, PA, Wolinsky, JS, Sajja, BR, He, R, Mehta, M, Books, W, Ford, C, Richards, T, Bowen, J, William Lindsey, J, Boulanger, Y, Duquette, P & Arnold, DL 2004, 'Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis', Multiple Sclerosis, vol. 10, no. SUPPL. 1.
Narayana, Ponnada A. ; Wolinsky, Jerry S. ; Sajja, Balasrinivasa R ; He, Renjie ; Mehta, Meghana ; Books, William ; Ford, Corey ; Richards, Todd ; Bowen, James ; William Lindsey, J. ; Boulanger, Yvan ; Duquette, Pierre ; Arnold, Douglas L. / Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis. In: Multiple Sclerosis. 2004 ; Vol. 10, No. SUPPL. 1.
@article{0374280629e44f3c8ab22bc091d49838,
title = "Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis",
abstract = "Multicentre baseline proton magnetic resonance spectroscopic data on primary progressive multiple sclerosis (PPMS) patients are acquired and analysed, using automatic analysis software. The metabolite ratios did not differ from centre to centre. The average N-acetylaspartate/creatine (NAA/Cr) ratio in PPMS was significantly lower compared to normal controls. No significant differences were observed in this ratio between lesion-containing regions (LCR) and normal-appearing tissues (NAT). Strong lipid resonances, even in the absence of lesions, are observed in the both grey and white matter in these patients. These observations suggest extensive diffuse and/or microscopic pathology in PPMS. No significant correlation between any of the metabolite ratios and the Extended Disability Scale Score (EDSS) or with other MR measures such as lesion burden and enhancement volumes is observed.",
keywords = "MRI, N-acetylaspartate, Primary progressive multiple sclerosis, Proton spectroscopic imaging",
author = "Narayana, {Ponnada A.} and Wolinsky, {Jerry S.} and Sajja, {Balasrinivasa R} and Renjie He and Meghana Mehta and William Books and Corey Ford and Todd Richards and James Bowen and {William Lindsey}, J. and Yvan Boulanger and Pierre Duquette and Arnold, {Douglas L.}",
year = "2004",
month = "6",
day = "1",
language = "English (US)",
volume = "10",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis

AU - Narayana, Ponnada A.

AU - Wolinsky, Jerry S.

AU - Sajja, Balasrinivasa R

AU - He, Renjie

AU - Mehta, Meghana

AU - Books, William

AU - Ford, Corey

AU - Richards, Todd

AU - Bowen, James

AU - William Lindsey, J.

AU - Boulanger, Yvan

AU - Duquette, Pierre

AU - Arnold, Douglas L.

PY - 2004/6/1

Y1 - 2004/6/1

N2 - Multicentre baseline proton magnetic resonance spectroscopic data on primary progressive multiple sclerosis (PPMS) patients are acquired and analysed, using automatic analysis software. The metabolite ratios did not differ from centre to centre. The average N-acetylaspartate/creatine (NAA/Cr) ratio in PPMS was significantly lower compared to normal controls. No significant differences were observed in this ratio between lesion-containing regions (LCR) and normal-appearing tissues (NAT). Strong lipid resonances, even in the absence of lesions, are observed in the both grey and white matter in these patients. These observations suggest extensive diffuse and/or microscopic pathology in PPMS. No significant correlation between any of the metabolite ratios and the Extended Disability Scale Score (EDSS) or with other MR measures such as lesion burden and enhancement volumes is observed.

AB - Multicentre baseline proton magnetic resonance spectroscopic data on primary progressive multiple sclerosis (PPMS) patients are acquired and analysed, using automatic analysis software. The metabolite ratios did not differ from centre to centre. The average N-acetylaspartate/creatine (NAA/Cr) ratio in PPMS was significantly lower compared to normal controls. No significant differences were observed in this ratio between lesion-containing regions (LCR) and normal-appearing tissues (NAT). Strong lipid resonances, even in the absence of lesions, are observed in the both grey and white matter in these patients. These observations suggest extensive diffuse and/or microscopic pathology in PPMS. No significant correlation between any of the metabolite ratios and the Extended Disability Scale Score (EDSS) or with other MR measures such as lesion burden and enhancement volumes is observed.

KW - MRI

KW - N-acetylaspartate

KW - Primary progressive multiple sclerosis

KW - Proton spectroscopic imaging

UR - http://www.scopus.com/inward/record.url?scp=3042639536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042639536&partnerID=8YFLogxK

M3 - Article

VL - 10

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - SUPPL. 1

ER -