Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy

Murali M. Yallapu, Shadi F Othman, Evan T. Curtis, Brij K. Gupta, Meena Jaggi, Subhash C. Chauhan

Research output: Contribution to journalArticle

289 Citations (Scopus)

Abstract

We have developed a multi-layer approach for the synthesis of water-dispersible superparamagnetic iron oxide nanoparticles for hyperthermia, magnetic resonance imaging (MRI) and drug delivery applications. In this approach, iron oxide core nanoparticles were obtained by precipitation of iron salts in the presence of ammonia and provided β-cyclodextrin and pluronic polymer (F127) coatings. This formulation (F127250) was highly water dispersible which allowed encapsulation of the anti-cancer drug(s) in β-cyclodextrin and pluronic polymer for sustained drug release. The F127250 formulation has exhibited superior hyperthermia effects over time under alternating magnetic field compared to pure magnetic nanoparticles (MNP) and β-cyclodextrin coated nanoparticles (CD200). Additionally, the improved MRI characteristics were also observed for the F127250 formulation in agar gel and in cisplatin resistant ovarian cancer cells (A12780CP) compared to MNP and CD200 formulations. Furthermore, the drug-loaded formulation of F127250 exhibited many folds of imaging contrast properties. Due to the internalization capacity of the F127250 formulation, its curcumin-loaded formulation (F127250-CUR) exhibited almost equivalent inhibition effects on A2780CP (ovarian), MDA-MB-231 (breast), and PC-3 (prostate) cancer cells even though curcumin release was only 40%. The improved therapeutic effects were verified by examining molecular effects using Western blotting and transmission electron microscopic (TEM) studies. F127250-CUR also exhibited haemocompatibility, suggesting a nanochemo-therapuetic agent for cancer therapy.

Original languageEnglish (US)
Pages (from-to)1890-1905
Number of pages16
JournalBiomaterials
Volume32
Issue number7
DOIs
StatePublished - Mar 1 2011

Fingerprint

Magnetic resonance
Nanoparticles
Magnetic Resonance Imaging
Cyclodextrins
Imaging techniques
Poloxamer
UCON 50-HB-5100
Curcumin
Neoplasms
Iron oxides
Polymers
Fever
Cells
Therapeutics
Drug Compounding
Water
Therapeutic Uses
Magnetic Fields
Drug delivery
Encapsulation

Keywords

  • Drug delivery
  • Hyperthermia
  • MRI
  • Magnetic nanoparticles
  • Multi-layer coating

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

Yallapu, M. M., Othman, S. F., Curtis, E. T., Gupta, B. K., Jaggi, M., & Chauhan, S. C. (2011). Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy. Biomaterials, 32(7), 1890-1905. https://doi.org/10.1016/j.biomaterials.2010.11.028

Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy. / Yallapu, Murali M.; Othman, Shadi F; Curtis, Evan T.; Gupta, Brij K.; Jaggi, Meena; Chauhan, Subhash C.

In: Biomaterials, Vol. 32, No. 7, 01.03.2011, p. 1890-1905.

Research output: Contribution to journalArticle

Yallapu, MM, Othman, SF, Curtis, ET, Gupta, BK, Jaggi, M & Chauhan, SC 2011, 'Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy', Biomaterials, vol. 32, no. 7, pp. 1890-1905. https://doi.org/10.1016/j.biomaterials.2010.11.028
Yallapu, Murali M. ; Othman, Shadi F ; Curtis, Evan T. ; Gupta, Brij K. ; Jaggi, Meena ; Chauhan, Subhash C. / Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy. In: Biomaterials. 2011 ; Vol. 32, No. 7. pp. 1890-1905.
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