Mucins in lung cancer: Diagnostic, prognostic, and therapeutic implications

Imayavaramban Lakshmanan, Moorthy Palanimuthu Ponnusamy, Muzafar A Macha, Dhanya Haridas, Prabin Dhangada Majhi, Sukwinder Kaur, Maneesh Jain, Surinder Kumar Batra, Apar Kishor P Ganti

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Aberrant expression of mucins is associated with cancer development and metastasis. An overexpression of few mucins contributes to oncogenesis by enhancing cancer cell growth and providing constitutive survival signals. This review focuses on the importance of mucins both in the normal bronchial epithelial cells and the malignant tumors of the lung and their contribution in the diagnosis and prognosis of lung cancer patients. During lung cancer progression, mucins either alone or through their interaction with many receptor tyrosine kinases mediate cell signals for growth and survival of cancer cells. Also, stage-specific expression of certain mucins, like MUC1, is associated with poor prognosis from lung cancer. Thus, mucins are emerging as attractive targets for developing novel therapeutic approaches for lung cancer. Several strategies targeting mucin expression and function are currently being investigated to control lung cancer progression.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalJournal of Thoracic Oncology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Mucins
Lung Neoplasms
Therapeutics
Neoplasms
Receptor Protein-Tyrosine Kinases
Growth
Cell Survival
Carcinogenesis
Epithelial Cells
Neoplasm Metastasis
Lung
Survival

Keywords

  • Aptamer
  • L-BLP25
  • Lung cancer
  • MUC1
  • MUC4
  • MUC5AC
  • MUC7
  • Mucin vaccines
  • Mucins
  • TG4010

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Mucins in lung cancer : Diagnostic, prognostic, and therapeutic implications. / Lakshmanan, Imayavaramban; Palanimuthu Ponnusamy, Moorthy; Macha, Muzafar A; Haridas, Dhanya; Majhi, Prabin Dhangada; Kaur, Sukwinder; Jain, Maneesh; Batra, Surinder Kumar; Ganti, Apar Kishor P.

In: Journal of Thoracic Oncology, Vol. 10, No. 1, 01.01.2015, p. 19-27.

Research output: Contribution to journalReview article

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