Mucins and Wnt/β-catenin signaling in gastrointestinal cancers: An unholy nexus

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

The Wnt/β-catenin signaling pathway is indispensable for embryonic development, maintenance of adult tissue homeostasis and repair of epithelial injury. Unsurprisingly, aberrations in this pathway occur frequently in many cancers and often result in increased nuclear β-catenin. While mutations in key pathway members, such as β-catenin and adenomatous polyposis coli, are early and frequent occurrences in most colorectal cancers (CRC), mutations in canonical pathway members are rare in pancreatic ductal adenocarcinoma (PDAC). Instead, in the majority of PDACs, indirect mechanisms such as promoter methylation, increased ligand secretion and decreased pathway inhibitor secretion work in concert to promote aberrant cytosolic/nuclear localization of β-catenin. Concomitant with alterations in β-catenin localization, changes in mucin expression and localization have been documented in multiple malignancies. Indeed, numerous studies over the years suggest an intricate and mutually regulatory relationship between mucins (MUCs) and β-catenin. In the current review, we summarize several studies that describe the relationship between mucins and β-catenin in gastrointestinal malignancies, with particular emphasis upon colorectal and pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)223-232
Number of pages10
JournalCarcinogenesis
Volume37
Issue number3
DOIs
StatePublished - Oct 17 2015

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Catenins
Gastrointestinal Neoplasms
Mucins
Colorectal Neoplasms
Neoplasms
Mutation
Wnt Signaling Pathway
Adenomatous Polyposis Coli
Secretory Pathway
Nexus
Pancreatic Neoplasms
Methylation
Embryonic Development
Adenocarcinoma
Homeostasis
Maintenance
Ligands
Wounds and Injuries

ASJC Scopus subject areas

  • Cancer Research

Cite this

Mucins and Wnt/β-catenin signaling in gastrointestinal cancers : An unholy nexus. / Pai, Priya; Rachagani, Satyanarayana; Dhawan, Punita; Batra, Surinder Kumar.

In: Carcinogenesis, Vol. 37, No. 3, 17.10.2015, p. 223-232.

Research output: Contribution to journalReview article

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