Mucin expression in pleomorphic adenoma of salivary gland: A potential role of MUC1 as a marker to predict recurrence

T. Hamada, S. Matsukita, M. Goto, S. Kitajima, Surinder Kumar Batra, T. Irimura, K. Sueyoshi, K. Sugihara, S. Yonezawa

Research output: Contribution to journalArticle

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Abstract

Background: Pleomorphic adenoma of the salivary gland (PA) is essentially a benign neoplasm. However, patients with recurrent PA are difficult to manage. There are rare reports on useful immunohistochemical markers to detect a high risk of recurrence when the primary lesions are resected. Aims: To find a new marker to predict the recurrence of PA. Methods: Primary lesions of PA were collected from nine patients showing subsequent recurrence and from 40 patients without recurrence during at least 10 years of follow up of the disease. Paraffin wax embedded tumour samples of the two groups were examined for the expression profiles of MUC1 (differentially glycosylated forms), MUC2, MUC4, MUC5AC, and MUC6 using immunohistochemistry. Several clinicopathological factors were also examined. Results: In univariate analysis of the factors examined, MUC1/DF3 high expression (more than 30% of the neoplastic cells stained) in the primary lesions was seen more frequently in patients with recurrence (four of nine) than in those without recurrence (three of 40; p = 0.011). Larger tumour size (more than 3.0 cm) of the primary PA was also a significant (p = 0.035) risk factor for the recurrence of PA. In multivariate analysis, only high expression of MUC1/DF3 was found to be a significant independent risk factor for the recurrence of PA (p = 0.021). Conclusions: Expression of MUC1/DF3 in PA is a useful marker to predict its recurrence. Those patients with PA showing positive MUC1/DF3 expression should be followed up carefully.

Original languageEnglish (US)
Pages (from-to)813-821
Number of pages9
JournalJournal of Clinical Pathology
Volume57
Issue number8
DOIs
StatePublished - Aug 1 2004

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Mucins
Recurrence
Pleomorphic Salivary Gland Adenoma
Neoplasms
Waxes
Paraffin
Statistical Factor Analysis
Multivariate Analysis
Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Mucin expression in pleomorphic adenoma of salivary gland : A potential role of MUC1 as a marker to predict recurrence. / Hamada, T.; Matsukita, S.; Goto, M.; Kitajima, S.; Batra, Surinder Kumar; Irimura, T.; Sueyoshi, K.; Sugihara, K.; Yonezawa, S.

In: Journal of Clinical Pathology, Vol. 57, No. 8, 01.08.2004, p. 813-821.

Research output: Contribution to journalArticle

Hamada, T, Matsukita, S, Goto, M, Kitajima, S, Batra, SK, Irimura, T, Sueyoshi, K, Sugihara, K & Yonezawa, S 2004, 'Mucin expression in pleomorphic adenoma of salivary gland: A potential role of MUC1 as a marker to predict recurrence', Journal of Clinical Pathology, vol. 57, no. 8, pp. 813-821. https://doi.org/10.1136/jcp.2003.014043
Hamada, T. ; Matsukita, S. ; Goto, M. ; Kitajima, S. ; Batra, Surinder Kumar ; Irimura, T. ; Sueyoshi, K. ; Sugihara, K. ; Yonezawa, S. / Mucin expression in pleomorphic adenoma of salivary gland : A potential role of MUC1 as a marker to predict recurrence. In: Journal of Clinical Pathology. 2004 ; Vol. 57, No. 8. pp. 813-821.
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T2 - A potential role of MUC1 as a marker to predict recurrence

AU - Hamada, T.

AU - Matsukita, S.

AU - Goto, M.

AU - Kitajima, S.

AU - Batra, Surinder Kumar

AU - Irimura, T.

AU - Sueyoshi, K.

AU - Sugihara, K.

AU - Yonezawa, S.

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N2 - Background: Pleomorphic adenoma of the salivary gland (PA) is essentially a benign neoplasm. However, patients with recurrent PA are difficult to manage. There are rare reports on useful immunohistochemical markers to detect a high risk of recurrence when the primary lesions are resected. Aims: To find a new marker to predict the recurrence of PA. Methods: Primary lesions of PA were collected from nine patients showing subsequent recurrence and from 40 patients without recurrence during at least 10 years of follow up of the disease. Paraffin wax embedded tumour samples of the two groups were examined for the expression profiles of MUC1 (differentially glycosylated forms), MUC2, MUC4, MUC5AC, and MUC6 using immunohistochemistry. Several clinicopathological factors were also examined. Results: In univariate analysis of the factors examined, MUC1/DF3 high expression (more than 30% of the neoplastic cells stained) in the primary lesions was seen more frequently in patients with recurrence (four of nine) than in those without recurrence (three of 40; p = 0.011). Larger tumour size (more than 3.0 cm) of the primary PA was also a significant (p = 0.035) risk factor for the recurrence of PA. In multivariate analysis, only high expression of MUC1/DF3 was found to be a significant independent risk factor for the recurrence of PA (p = 0.021). Conclusions: Expression of MUC1/DF3 in PA is a useful marker to predict its recurrence. Those patients with PA showing positive MUC1/DF3 expression should be followed up carefully.

AB - Background: Pleomorphic adenoma of the salivary gland (PA) is essentially a benign neoplasm. However, patients with recurrent PA are difficult to manage. There are rare reports on useful immunohistochemical markers to detect a high risk of recurrence when the primary lesions are resected. Aims: To find a new marker to predict the recurrence of PA. Methods: Primary lesions of PA were collected from nine patients showing subsequent recurrence and from 40 patients without recurrence during at least 10 years of follow up of the disease. Paraffin wax embedded tumour samples of the two groups were examined for the expression profiles of MUC1 (differentially glycosylated forms), MUC2, MUC4, MUC5AC, and MUC6 using immunohistochemistry. Several clinicopathological factors were also examined. Results: In univariate analysis of the factors examined, MUC1/DF3 high expression (more than 30% of the neoplastic cells stained) in the primary lesions was seen more frequently in patients with recurrence (four of nine) than in those without recurrence (three of 40; p = 0.011). Larger tumour size (more than 3.0 cm) of the primary PA was also a significant (p = 0.035) risk factor for the recurrence of PA. In multivariate analysis, only high expression of MUC1/DF3 was found to be a significant independent risk factor for the recurrence of PA (p = 0.021). Conclusions: Expression of MUC1/DF3 in PA is a useful marker to predict its recurrence. Those patients with PA showing positive MUC1/DF3 expression should be followed up carefully.

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