MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas

M. Saitou, M. Goto, M. Horinouchi, S. Tamada, K. Nagata, T. Hamada, M. Osako, S. Takao, Surinder Kumar Batra, T. Aikou, K. Imai, S. Yonezawa

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Abstract

Background: Many patients with invasive ductal carcinoma of the pancreas (IDC) have a poor outcome. MUC4 expression has been implicated as a marker for diagnosis and progression of IDC, but there are no studies of the relation between MUC4 expression and patient prognosis in IDC. Aims: To investigate the prognostic significance of MUC4 expression in IDC. Methods: The expression profiles of MUC4, ErbB2, p27, and MUC1 were investigated in IDC tissues from 135 patients by means of immunohistochemistry. Results: MUC4 was expressed in 43 of the 135 patients with IDC (31.9%). The survival of 21 patients with high MUC4 expression (>20% of neoplastic cells stained) was significantly worse than that of the 114 patients with low MUC4 expression (<20% of neoplastic cells stained) (p = 0.0043). Univariate analysis showed that high MUC4 expression (p = 0.0061), large primary tumour status (>T2) (p = 0.0436), distant metastasis (p = 0.0383), lymphatic invasion (p = 0.0243), and surgical margins (p = 0.0333) were significant risk factors affecting the outcome of patients with IDC. Backward stepwise multivariate analysis showed that MUC4 expression (p = 0.0121), lymph node metastasis (p = 0.0245), and lymphatic invasion (p = 0.0239) were significant independent risk factors. ErbB2, p27, and MUC1 were not independent risk factors. Conclusions: This study shows that MUC4 expression in IDC is a new independent factor for poor prognosis and predicts the outcome of patients with IDC.

Original languageEnglish (US)
Pages (from-to)845-852
Number of pages8
JournalJournal of Clinical Pathology
Volume58
Issue number8
DOIs
StatePublished - Aug 1 2005

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Pancreatic Ductal Carcinoma
Neoplasm Metastasis
Multivariate Analysis
Lymph Nodes
Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Saitou, M., Goto, M., Horinouchi, M., Tamada, S., Nagata, K., Hamada, T., ... Yonezawa, S. (2005). MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. Journal of Clinical Pathology, 58(8), 845-852. https://doi.org/10.1136/jcp.2004.023572

MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. / Saitou, M.; Goto, M.; Horinouchi, M.; Tamada, S.; Nagata, K.; Hamada, T.; Osako, M.; Takao, S.; Batra, Surinder Kumar; Aikou, T.; Imai, K.; Yonezawa, S.

In: Journal of Clinical Pathology, Vol. 58, No. 8, 01.08.2005, p. 845-852.

Research output: Contribution to journalArticle

Saitou, M, Goto, M, Horinouchi, M, Tamada, S, Nagata, K, Hamada, T, Osako, M, Takao, S, Batra, SK, Aikou, T, Imai, K & Yonezawa, S 2005, 'MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas', Journal of Clinical Pathology, vol. 58, no. 8, pp. 845-852. https://doi.org/10.1136/jcp.2004.023572
Saitou, M. ; Goto, M. ; Horinouchi, M. ; Tamada, S. ; Nagata, K. ; Hamada, T. ; Osako, M. ; Takao, S. ; Batra, Surinder Kumar ; Aikou, T. ; Imai, K. ; Yonezawa, S. / MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. In: Journal of Clinical Pathology. 2005 ; Vol. 58, No. 8. pp. 845-852.
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abstract = "Background: Many patients with invasive ductal carcinoma of the pancreas (IDC) have a poor outcome. MUC4 expression has been implicated as a marker for diagnosis and progression of IDC, but there are no studies of the relation between MUC4 expression and patient prognosis in IDC. Aims: To investigate the prognostic significance of MUC4 expression in IDC. Methods: The expression profiles of MUC4, ErbB2, p27, and MUC1 were investigated in IDC tissues from 135 patients by means of immunohistochemistry. Results: MUC4 was expressed in 43 of the 135 patients with IDC (31.9{\%}). The survival of 21 patients with high MUC4 expression (>20{\%} of neoplastic cells stained) was significantly worse than that of the 114 patients with low MUC4 expression (<20{\%} of neoplastic cells stained) (p = 0.0043). Univariate analysis showed that high MUC4 expression (p = 0.0061), large primary tumour status (>T2) (p = 0.0436), distant metastasis (p = 0.0383), lymphatic invasion (p = 0.0243), and surgical margins (p = 0.0333) were significant risk factors affecting the outcome of patients with IDC. Backward stepwise multivariate analysis showed that MUC4 expression (p = 0.0121), lymph node metastasis (p = 0.0245), and lymphatic invasion (p = 0.0239) were significant independent risk factors. ErbB2, p27, and MUC1 were not independent risk factors. Conclusions: This study shows that MUC4 expression in IDC is a new independent factor for poor prognosis and predicts the outcome of patients with IDC.",
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T1 - MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas

AU - Saitou, M.

AU - Goto, M.

AU - Horinouchi, M.

AU - Tamada, S.

AU - Nagata, K.

AU - Hamada, T.

AU - Osako, M.

AU - Takao, S.

AU - Batra, Surinder Kumar

AU - Aikou, T.

AU - Imai, K.

AU - Yonezawa, S.

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Background: Many patients with invasive ductal carcinoma of the pancreas (IDC) have a poor outcome. MUC4 expression has been implicated as a marker for diagnosis and progression of IDC, but there are no studies of the relation between MUC4 expression and patient prognosis in IDC. Aims: To investigate the prognostic significance of MUC4 expression in IDC. Methods: The expression profiles of MUC4, ErbB2, p27, and MUC1 were investigated in IDC tissues from 135 patients by means of immunohistochemistry. Results: MUC4 was expressed in 43 of the 135 patients with IDC (31.9%). The survival of 21 patients with high MUC4 expression (>20% of neoplastic cells stained) was significantly worse than that of the 114 patients with low MUC4 expression (<20% of neoplastic cells stained) (p = 0.0043). Univariate analysis showed that high MUC4 expression (p = 0.0061), large primary tumour status (>T2) (p = 0.0436), distant metastasis (p = 0.0383), lymphatic invasion (p = 0.0243), and surgical margins (p = 0.0333) were significant risk factors affecting the outcome of patients with IDC. Backward stepwise multivariate analysis showed that MUC4 expression (p = 0.0121), lymph node metastasis (p = 0.0245), and lymphatic invasion (p = 0.0239) were significant independent risk factors. ErbB2, p27, and MUC1 were not independent risk factors. Conclusions: This study shows that MUC4 expression in IDC is a new independent factor for poor prognosis and predicts the outcome of patients with IDC.

AB - Background: Many patients with invasive ductal carcinoma of the pancreas (IDC) have a poor outcome. MUC4 expression has been implicated as a marker for diagnosis and progression of IDC, but there are no studies of the relation between MUC4 expression and patient prognosis in IDC. Aims: To investigate the prognostic significance of MUC4 expression in IDC. Methods: The expression profiles of MUC4, ErbB2, p27, and MUC1 were investigated in IDC tissues from 135 patients by means of immunohistochemistry. Results: MUC4 was expressed in 43 of the 135 patients with IDC (31.9%). The survival of 21 patients with high MUC4 expression (>20% of neoplastic cells stained) was significantly worse than that of the 114 patients with low MUC4 expression (<20% of neoplastic cells stained) (p = 0.0043). Univariate analysis showed that high MUC4 expression (p = 0.0061), large primary tumour status (>T2) (p = 0.0436), distant metastasis (p = 0.0383), lymphatic invasion (p = 0.0243), and surgical margins (p = 0.0333) were significant risk factors affecting the outcome of patients with IDC. Backward stepwise multivariate analysis showed that MUC4 expression (p = 0.0121), lymph node metastasis (p = 0.0245), and lymphatic invasion (p = 0.0239) were significant independent risk factors. ErbB2, p27, and MUC1 were not independent risk factors. Conclusions: This study shows that MUC4 expression in IDC is a new independent factor for poor prognosis and predicts the outcome of patients with IDC.

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U2 - 10.1136/jcp.2004.023572

DO - 10.1136/jcp.2004.023572

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