MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma

Hideaki Tsutsumida, Masamichi Goto, Shinichi Kitajima, Ichiro Kubota, Yasunobu Hirotsu, Joeji Wakimoto, Surinder Kumar Batra, Kohzoh Imai, Suguru Yonezawa

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The mortality of lung cancer remains high, despite improved diagnostic techniques that allow small lung tumors to be detected. In this study, we evaluated the prognostic significance of the tracheal mucin MUC4 by immunohistochemical investigation of the expression profiles of MUC4, ErbB2, p27 and MUC1 in lung adenocarcinoma specimens (non-bronchiolo-alveolar type, ≤3 cm) from 185 patients. MUC4 is a membrane mucin, similarly to MUC1, and in addition MUC4 functions as an intra-membrane ligand for receptor tyrosine kinase ErbB2 and is associated with regulation of p27. However, MUC4 expression was found to be unrelated to expression of MUC1, ErbB2 and p27 in small-sized lung adenocarcinomas. The disease-free interval (DFI) and survival rate of 25 patients with high MUC4 expression (≥25% of neoplastic cells stained) were significantly lower than those of 160 patients with low MUC4 expression (<25% of neoplastic cells stained) (P < 0.05), whereas ErbB2 and p27 expression showed no significant correlation with DFI and survival. Univariate analysis showed that high MUC4 and p27 expression correlated with blood vessel invasion (P = 0.0004), and MUC4 expression was frequently detected in regions of stromal invasion. In addition, the survival rate of stage IA patients with high MUC4 expression was significantly lower than that of stage IA patients with low MUC4 expression (P < 0.05). In conclusion, high MUC4 expression in small-sized lung adenocarcinomas correlates with a short DFI and a poor survival rate. Therefore, MUC4 expression might be a new independent factor for prediction of outcome and indication of poor prognosis in lung adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)195-203
Number of pages9
JournalLung Cancer
Volume55
Issue number2
DOIs
StatePublished - Feb 1 2007

Fingerprint

Survival Rate
Mucins
Disease-Free Survival
Membranes
Receptor Protein-Tyrosine Kinases
Blood Vessels
Lung Neoplasms
Adenocarcinoma of lung
Ligands
Lung
Mortality
Neoplasms

Keywords

  • Adenocarcinoma
  • Immunohistochemistry
  • Lung cancer
  • MUC4
  • Mucin
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Tsutsumida, H., Goto, M., Kitajima, S., Kubota, I., Hirotsu, Y., Wakimoto, J., ... Yonezawa, S. (2007). MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma. Lung Cancer, 55(2), 195-203. https://doi.org/10.1016/j.lungcan.2006.10.013

MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma. / Tsutsumida, Hideaki; Goto, Masamichi; Kitajima, Shinichi; Kubota, Ichiro; Hirotsu, Yasunobu; Wakimoto, Joeji; Batra, Surinder Kumar; Imai, Kohzoh; Yonezawa, Suguru.

In: Lung Cancer, Vol. 55, No. 2, 01.02.2007, p. 195-203.

Research output: Contribution to journalArticle

Tsutsumida, H, Goto, M, Kitajima, S, Kubota, I, Hirotsu, Y, Wakimoto, J, Batra, SK, Imai, K & Yonezawa, S 2007, 'MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma', Lung Cancer, vol. 55, no. 2, pp. 195-203. https://doi.org/10.1016/j.lungcan.2006.10.013
Tsutsumida H, Goto M, Kitajima S, Kubota I, Hirotsu Y, Wakimoto J et al. MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma. Lung Cancer. 2007 Feb 1;55(2):195-203. https://doi.org/10.1016/j.lungcan.2006.10.013
Tsutsumida, Hideaki ; Goto, Masamichi ; Kitajima, Shinichi ; Kubota, Ichiro ; Hirotsu, Yasunobu ; Wakimoto, Joeji ; Batra, Surinder Kumar ; Imai, Kohzoh ; Yonezawa, Suguru. / MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma. In: Lung Cancer. 2007 ; Vol. 55, No. 2. pp. 195-203.
@article{3c8b34b6447a424abf62472fc48c3809,
title = "MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma",
abstract = "The mortality of lung cancer remains high, despite improved diagnostic techniques that allow small lung tumors to be detected. In this study, we evaluated the prognostic significance of the tracheal mucin MUC4 by immunohistochemical investigation of the expression profiles of MUC4, ErbB2, p27 and MUC1 in lung adenocarcinoma specimens (non-bronchiolo-alveolar type, ≤3 cm) from 185 patients. MUC4 is a membrane mucin, similarly to MUC1, and in addition MUC4 functions as an intra-membrane ligand for receptor tyrosine kinase ErbB2 and is associated with regulation of p27. However, MUC4 expression was found to be unrelated to expression of MUC1, ErbB2 and p27 in small-sized lung adenocarcinomas. The disease-free interval (DFI) and survival rate of 25 patients with high MUC4 expression (≥25{\%} of neoplastic cells stained) were significantly lower than those of 160 patients with low MUC4 expression (<25{\%} of neoplastic cells stained) (P < 0.05), whereas ErbB2 and p27 expression showed no significant correlation with DFI and survival. Univariate analysis showed that high MUC4 and p27 expression correlated with blood vessel invasion (P = 0.0004), and MUC4 expression was frequently detected in regions of stromal invasion. In addition, the survival rate of stage IA patients with high MUC4 expression was significantly lower than that of stage IA patients with low MUC4 expression (P < 0.05). In conclusion, high MUC4 expression in small-sized lung adenocarcinomas correlates with a short DFI and a poor survival rate. Therefore, MUC4 expression might be a new independent factor for prediction of outcome and indication of poor prognosis in lung adenocarcinoma.",
keywords = "Adenocarcinoma, Immunohistochemistry, Lung cancer, MUC4, Mucin, Prognosis",
author = "Hideaki Tsutsumida and Masamichi Goto and Shinichi Kitajima and Ichiro Kubota and Yasunobu Hirotsu and Joeji Wakimoto and Batra, {Surinder Kumar} and Kohzoh Imai and Suguru Yonezawa",
year = "2007",
month = "2",
day = "1",
doi = "10.1016/j.lungcan.2006.10.013",
language = "English (US)",
volume = "55",
pages = "195--203",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma

AU - Tsutsumida, Hideaki

AU - Goto, Masamichi

AU - Kitajima, Shinichi

AU - Kubota, Ichiro

AU - Hirotsu, Yasunobu

AU - Wakimoto, Joeji

AU - Batra, Surinder Kumar

AU - Imai, Kohzoh

AU - Yonezawa, Suguru

PY - 2007/2/1

Y1 - 2007/2/1

N2 - The mortality of lung cancer remains high, despite improved diagnostic techniques that allow small lung tumors to be detected. In this study, we evaluated the prognostic significance of the tracheal mucin MUC4 by immunohistochemical investigation of the expression profiles of MUC4, ErbB2, p27 and MUC1 in lung adenocarcinoma specimens (non-bronchiolo-alveolar type, ≤3 cm) from 185 patients. MUC4 is a membrane mucin, similarly to MUC1, and in addition MUC4 functions as an intra-membrane ligand for receptor tyrosine kinase ErbB2 and is associated with regulation of p27. However, MUC4 expression was found to be unrelated to expression of MUC1, ErbB2 and p27 in small-sized lung adenocarcinomas. The disease-free interval (DFI) and survival rate of 25 patients with high MUC4 expression (≥25% of neoplastic cells stained) were significantly lower than those of 160 patients with low MUC4 expression (<25% of neoplastic cells stained) (P < 0.05), whereas ErbB2 and p27 expression showed no significant correlation with DFI and survival. Univariate analysis showed that high MUC4 and p27 expression correlated with blood vessel invasion (P = 0.0004), and MUC4 expression was frequently detected in regions of stromal invasion. In addition, the survival rate of stage IA patients with high MUC4 expression was significantly lower than that of stage IA patients with low MUC4 expression (P < 0.05). In conclusion, high MUC4 expression in small-sized lung adenocarcinomas correlates with a short DFI and a poor survival rate. Therefore, MUC4 expression might be a new independent factor for prediction of outcome and indication of poor prognosis in lung adenocarcinoma.

AB - The mortality of lung cancer remains high, despite improved diagnostic techniques that allow small lung tumors to be detected. In this study, we evaluated the prognostic significance of the tracheal mucin MUC4 by immunohistochemical investigation of the expression profiles of MUC4, ErbB2, p27 and MUC1 in lung adenocarcinoma specimens (non-bronchiolo-alveolar type, ≤3 cm) from 185 patients. MUC4 is a membrane mucin, similarly to MUC1, and in addition MUC4 functions as an intra-membrane ligand for receptor tyrosine kinase ErbB2 and is associated with regulation of p27. However, MUC4 expression was found to be unrelated to expression of MUC1, ErbB2 and p27 in small-sized lung adenocarcinomas. The disease-free interval (DFI) and survival rate of 25 patients with high MUC4 expression (≥25% of neoplastic cells stained) were significantly lower than those of 160 patients with low MUC4 expression (<25% of neoplastic cells stained) (P < 0.05), whereas ErbB2 and p27 expression showed no significant correlation with DFI and survival. Univariate analysis showed that high MUC4 and p27 expression correlated with blood vessel invasion (P = 0.0004), and MUC4 expression was frequently detected in regions of stromal invasion. In addition, the survival rate of stage IA patients with high MUC4 expression was significantly lower than that of stage IA patients with low MUC4 expression (P < 0.05). In conclusion, high MUC4 expression in small-sized lung adenocarcinomas correlates with a short DFI and a poor survival rate. Therefore, MUC4 expression might be a new independent factor for prediction of outcome and indication of poor prognosis in lung adenocarcinoma.

KW - Adenocarcinoma

KW - Immunohistochemistry

KW - Lung cancer

KW - MUC4

KW - Mucin

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=33846092127&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846092127&partnerID=8YFLogxK

U2 - 10.1016/j.lungcan.2006.10.013

DO - 10.1016/j.lungcan.2006.10.013

M3 - Article

VL - 55

SP - 195

EP - 203

JO - Lung Cancer

JF - Lung Cancer

SN - 0169-5002

IS - 2

ER -