38 Citations (Scopus)

Abstract

MUC1, a type I transmembrane protein, is significantly overexpressed and aberrantly glycosylated in tumors of epithelial origin. By virtue of its aberrant signaling due to loss of apical-basal polarity in cancer, MUC1 regulates the metabolite flux at multiple levels. Serving as a transcriptional co-activator, MUC1 directly regulates expression of metabolic genes. By regulating receptor tyrosine kinase signaling, MUC1 facilitates production of biosynthetic intermediates required for cell growth. Also, via direct interactions, MUC1 modulates the activity/stability of enzymes and transcription factors that directly regulate metabolic functions. Additionally, by modulation of autophagy, levels of reactive oxygen species, and metabolite flux, MUC1 facilitates cancer cell survival under hypoxic and nutrient-deprived conditions. This article provides a comprehensive review of recent literature on novel metabolic functions of MUC1.

Original languageEnglish (US)
Pages (from-to)126-135
Number of pages10
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1845
Issue number2
DOIs
StatePublished - Apr 1 2014

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Enzyme Stability
Neoplasms
Autophagy
Receptor Protein-Tyrosine Kinases
Reactive Oxygen Species
Cell Survival
Transcription Factors
Gene Expression
Food
Growth
Proteins

Keywords

  • Cancer metabolism
  • Glycolysis
  • MUC1
  • Nutrient stress and carbon flux

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

MUC1 : A novel metabolic master regulator. / Mehla, Kamiya; Singh, Pankaj.

In: Biochimica et Biophysica Acta - Reviews on Cancer, Vol. 1845, No. 2, 01.04.2014, p. 126-135.

Research output: Contribution to journalArticle

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