MSH1-induced non-genetic variation provides a source of phenotypic diversity in Sorghum bicolor

Roberto De La Rosa Santamaria, Mon Ray Shao, Guomei Wang, David O. Nino-Liu, Hardik Kundariya, Yashitola Wamboldt, Ismail Dweikat, Sally A. Mackenzie

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

MutS Homolog 1 (MSH1) encodes a plant-specific protein that functions in mitochondria and chloroplasts. We showed previously that disruption or suppression of the MSH1 gene results in a process of developmental reprogramming that is heritable and non-genetic in subsequent generations. In Arabidopsis, this developmental reprogramming process is accompanied by striking changes in gene expression of organellar and stress response genes. This developmentally reprogrammed state, when used in crossing, results in a range of variation for plant growth potential. Here we investigate the implications of MSH1 modulation in a crop species. We found that MSH1-mediated phenotypic variation in Sorghum bicolor is heritable and potentially valuable for crop breeding. We observed phenotypic variation for grain yield, plant height, flowering time, panicle architecture, and above-ground biomass. Focusing on grain yield and plant height, we found some lines that appeared to respond to selection. Based on amenability of this system to implementation in a range of crops, and the scope of phenotypic variation that is derived, our results suggest that MSH1 suppression provides a novel approach for breeding in crops.

Original languageEnglish (US)
Article numbere108407
JournalPloS one
Volume9
Issue number10
DOIs
StatePublished - Oct 27 2014

Fingerprint

Sorghum
Sorghum bicolor
phenotypic variation
Crops
plant breeding
Breeding
grain yield
Plant Proteins
Genes
Chloroplasts
crops
Arabidopsis
Biomass
aboveground biomass
Mitochondria
stress response
mitochondria
genes
chloroplasts
Gene expression

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

De La Rosa Santamaria, R., Shao, M. R., Wang, G., Nino-Liu, D. O., Kundariya, H., Wamboldt, Y., ... Mackenzie, S. A. (2014). MSH1-induced non-genetic variation provides a source of phenotypic diversity in Sorghum bicolor. PloS one, 9(10), [e108407]. https://doi.org/10.1371/journal.pone.0108407

MSH1-induced non-genetic variation provides a source of phenotypic diversity in Sorghum bicolor. / De La Rosa Santamaria, Roberto; Shao, Mon Ray; Wang, Guomei; Nino-Liu, David O.; Kundariya, Hardik; Wamboldt, Yashitola; Dweikat, Ismail; Mackenzie, Sally A.

In: PloS one, Vol. 9, No. 10, e108407, 27.10.2014.

Research output: Contribution to journalArticle

De La Rosa Santamaria, R, Shao, MR, Wang, G, Nino-Liu, DO, Kundariya, H, Wamboldt, Y, Dweikat, I & Mackenzie, SA 2014, 'MSH1-induced non-genetic variation provides a source of phenotypic diversity in Sorghum bicolor', PloS one, vol. 9, no. 10, e108407. https://doi.org/10.1371/journal.pone.0108407
De La Rosa Santamaria R, Shao MR, Wang G, Nino-Liu DO, Kundariya H, Wamboldt Y et al. MSH1-induced non-genetic variation provides a source of phenotypic diversity in Sorghum bicolor. PloS one. 2014 Oct 27;9(10). e108407. https://doi.org/10.1371/journal.pone.0108407
De La Rosa Santamaria, Roberto ; Shao, Mon Ray ; Wang, Guomei ; Nino-Liu, David O. ; Kundariya, Hardik ; Wamboldt, Yashitola ; Dweikat, Ismail ; Mackenzie, Sally A. / MSH1-induced non-genetic variation provides a source of phenotypic diversity in Sorghum bicolor. In: PloS one. 2014 ; Vol. 9, No. 10.
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