MRI of spontaneous fluctuations after acute cerebral ischemia in nonhuman primates

Yutong Liu, Helen D'Arceuil, Julian He, Mike Duggan, Gilberto Gonzalez, Johnny Pryor, Alex De Crespigny

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: To study the spontaneous low-frequency blood oxygenation level-dependent (BOLD) functional MRI (fMRI) signal fluctuations during hyperacute focal cerebral ischemia. Materials and Methods: A stroke model in nonhuman primates (macaques) was used in this study. Spontaneous fluctuations were recorded using a series of gradient-recalled echo (GRE) echo-planar imaging (EPI) images. Fast Fourier transformation (FFT) was performed on the serial EPI data to calculate the frequency and magnitude of the spontaneous fluctuations. Diffusion tensor imaging (DTI) and perfusion-weighted imaging (PWI) were preformed to detect the ischemic lesion. Results: The frequency of these fluctuations decreased in the periinfarct tissue in the ipsilateral hemisphere, while their magnitude increased. This area of abnormal signal fluctuations often extended beyond the hyperacute diffusion/perfusion abnormality. Conclusion: This study suggests that measurement of the spontaneous fMRI signal fluctuations provides different information than is available from diffusion/perfusion or T2-weighted MRI.

Original languageEnglish (US)
Pages (from-to)1112-1116
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume26
Issue number4
DOIs
StatePublished - Oct 1 2007

Fingerprint

Echo-Planar Imaging
Brain Ischemia
Primates
Perfusion
Magnetic Resonance Imaging
Diffusion Tensor Imaging
Perfusion Imaging
Macaca
Stroke

Keywords

  • MRI
  • Spontaneous fluctuations
  • Stroke
  • Vasomotion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Liu, Y., D'Arceuil, H., He, J., Duggan, M., Gonzalez, G., Pryor, J., & De Crespigny, A. (2007). MRI of spontaneous fluctuations after acute cerebral ischemia in nonhuman primates. Journal of Magnetic Resonance Imaging, 26(4), 1112-1116. https://doi.org/10.1002/jmri.21131

MRI of spontaneous fluctuations after acute cerebral ischemia in nonhuman primates. / Liu, Yutong; D'Arceuil, Helen; He, Julian; Duggan, Mike; Gonzalez, Gilberto; Pryor, Johnny; De Crespigny, Alex.

In: Journal of Magnetic Resonance Imaging, Vol. 26, No. 4, 01.10.2007, p. 1112-1116.

Research output: Contribution to journalArticle

Liu, Y, D'Arceuil, H, He, J, Duggan, M, Gonzalez, G, Pryor, J & De Crespigny, A 2007, 'MRI of spontaneous fluctuations after acute cerebral ischemia in nonhuman primates', Journal of Magnetic Resonance Imaging, vol. 26, no. 4, pp. 1112-1116. https://doi.org/10.1002/jmri.21131
Liu, Yutong ; D'Arceuil, Helen ; He, Julian ; Duggan, Mike ; Gonzalez, Gilberto ; Pryor, Johnny ; De Crespigny, Alex. / MRI of spontaneous fluctuations after acute cerebral ischemia in nonhuman primates. In: Journal of Magnetic Resonance Imaging. 2007 ; Vol. 26, No. 4. pp. 1112-1116.
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