MR imaging appearance of childhood adrenoleukodystrophy with auditory, visual, and motor pathway involvement.

M. E. Jensen, R. W. Sawyer, I. F. Braun, William B Rizzo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Childhood adrenoleukodystrophy is an X chromosome-linked disorder characterized by progressive demyelination of cerebral white matter and adrenal insufficiency. Magnetic resonance (MR) imaging was performed in 15 patients with symptomatic disease and three with presymptomatic disease. MR imaging findings were abnormal only in symptomatic patients. Major sites of disease were the occipital, parietal, and temporal lobes, with all patients showing involvement of occipital lobes, optic radiations, and splenium of the corpus callosum. Follow-up images obtained in four patients demonstrated a posterior-to-anterior progression of disease. Correlation of results from MR imaging with those from evoked potential studies indicated that MR imaging was the method of choice for detecting demyelination of visual, auditory, and motor systems in adrenoleukodystrophy.

Original languageEnglish (US)
Pages (from-to)53-66
Number of pages14
JournalRadiographics : a review publication of the Radiological Society of North America, Inc
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1990

Fingerprint

Adrenoleukodystrophy
Auditory Pathways
Efferent Pathways
Visual Pathways
Magnetic Resonance Imaging
Occipital Lobe
Demyelinating Diseases
Chromosome Disorders
Asymptomatic Diseases
Adrenal Insufficiency
Parietal Lobe
Corpus Callosum
X Chromosome
Temporal Lobe
Evoked Potentials
Disease Progression
Radiation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

MR imaging appearance of childhood adrenoleukodystrophy with auditory, visual, and motor pathway involvement. / Jensen, M. E.; Sawyer, R. W.; Braun, I. F.; Rizzo, William B.

In: Radiographics : a review publication of the Radiological Society of North America, Inc, Vol. 10, No. 1, 01.01.1990, p. 53-66.

Research output: Contribution to journalArticle

@article{297d344185f5441094908c80018f51c4,
title = "MR imaging appearance of childhood adrenoleukodystrophy with auditory, visual, and motor pathway involvement.",
abstract = "Childhood adrenoleukodystrophy is an X chromosome-linked disorder characterized by progressive demyelination of cerebral white matter and adrenal insufficiency. Magnetic resonance (MR) imaging was performed in 15 patients with symptomatic disease and three with presymptomatic disease. MR imaging findings were abnormal only in symptomatic patients. Major sites of disease were the occipital, parietal, and temporal lobes, with all patients showing involvement of occipital lobes, optic radiations, and splenium of the corpus callosum. Follow-up images obtained in four patients demonstrated a posterior-to-anterior progression of disease. Correlation of results from MR imaging with those from evoked potential studies indicated that MR imaging was the method of choice for detecting demyelination of visual, auditory, and motor systems in adrenoleukodystrophy.",
author = "Jensen, {M. E.} and Sawyer, {R. W.} and Braun, {I. F.} and Rizzo, {William B}",
year = "1990",
month = "1",
day = "1",
doi = "10.1148/radiographics.10.1.2296697",
language = "English (US)",
volume = "10",
pages = "53--66",
journal = "Radiographics",
issn = "0271-5333",
publisher = "Radiological Society of North America Inc.",
number = "1",

}

TY - JOUR

T1 - MR imaging appearance of childhood adrenoleukodystrophy with auditory, visual, and motor pathway involvement.

AU - Jensen, M. E.

AU - Sawyer, R. W.

AU - Braun, I. F.

AU - Rizzo, William B

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Childhood adrenoleukodystrophy is an X chromosome-linked disorder characterized by progressive demyelination of cerebral white matter and adrenal insufficiency. Magnetic resonance (MR) imaging was performed in 15 patients with symptomatic disease and three with presymptomatic disease. MR imaging findings were abnormal only in symptomatic patients. Major sites of disease were the occipital, parietal, and temporal lobes, with all patients showing involvement of occipital lobes, optic radiations, and splenium of the corpus callosum. Follow-up images obtained in four patients demonstrated a posterior-to-anterior progression of disease. Correlation of results from MR imaging with those from evoked potential studies indicated that MR imaging was the method of choice for detecting demyelination of visual, auditory, and motor systems in adrenoleukodystrophy.

AB - Childhood adrenoleukodystrophy is an X chromosome-linked disorder characterized by progressive demyelination of cerebral white matter and adrenal insufficiency. Magnetic resonance (MR) imaging was performed in 15 patients with symptomatic disease and three with presymptomatic disease. MR imaging findings were abnormal only in symptomatic patients. Major sites of disease were the occipital, parietal, and temporal lobes, with all patients showing involvement of occipital lobes, optic radiations, and splenium of the corpus callosum. Follow-up images obtained in four patients demonstrated a posterior-to-anterior progression of disease. Correlation of results from MR imaging with those from evoked potential studies indicated that MR imaging was the method of choice for detecting demyelination of visual, auditory, and motor systems in adrenoleukodystrophy.

UR - http://www.scopus.com/inward/record.url?scp=0025085183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025085183&partnerID=8YFLogxK

U2 - 10.1148/radiographics.10.1.2296697

DO - 10.1148/radiographics.10.1.2296697

M3 - Article

VL - 10

SP - 53

EP - 66

JO - Radiographics

JF - Radiographics

SN - 0271-5333

IS - 1

ER -