MR identification of white matter abnormalities in multiple sclerosis

A comparison between 1.5 T and 4 T

Mark D Keiper, Robert I. Grossman, Joshua A. Hirsch, Lizann Bolinger, Ingrid L. Ott, Lois J. Mannon, Curtis P. Langlotz, Dennis L. Kolson

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE: Although MR spectroscopy and functional MR imaging of the brain have been successful at 4 T, conventional fast spin-echo imaging of the brain at 4 T has not been adequately evaluated. The purpose of this study was to compare the detection of white matter abnormalities in multiple sclerosis (MS) at 1.5 T and 4 T. METHODS: Fifteen patients with clinically definite MS were imaged at both 1.5 T and 4 T within a 1-week period. Comparison was made between fast spin-echo long-TR images at both field strengths. Pulse sequences were tailored to maximize resolution and signal-to-noise ratio in clinically relevant imaging times (< 7 min). Four interpreters independently reviewed the images obtained at both field strengths in separate sessions and evaluated them for lesion identification, size, characterization, and subjective resolution. Differences in interpretations at 1.5 T and 4 T were subsequently recorded. RESULTS: Images obtained at 4 T showed a mean of 88 more lesions as compared with images obtained at 1.5 T. All the lesions measured less than 5 mm and were typically aligned along perivascular spaces. Twenty-five consensually identified lesions on 4-T images were not seen at all on 1.5-T images. Moreover, 4-T images showed 56 additional consensually identified lesions, which were indistinct and seen only in retrospect on 1.5-T images. These lesions were frequently (n = 48) identified in large confluent areas of white matter signal intensity abnormality at 1.5 T. All observers also agreed that 4-T images subjectively enhanced the perception of normal perivascular spaces and small perivascular lesions CONCLUSION: MR imaging at 4 T can depict white matter abnormalities in MS patients not detectable at 1.5 T through higher resolution with comparable signal-to-noise ratio and imaging times.

Original languageEnglish (US)
Pages (from-to)1489-1493
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume19
Issue number8
StatePublished - Sep 1 1998

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Multiple Sclerosis
Signal-To-Noise Ratio
Functional Neuroimaging
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Brain
White Matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Keiper, M. D., Grossman, R. I., Hirsch, J. A., Bolinger, L., Ott, I. L., Mannon, L. J., ... Kolson, D. L. (1998). MR identification of white matter abnormalities in multiple sclerosis: A comparison between 1.5 T and 4 T. American Journal of Neuroradiology, 19(8), 1489-1493.

MR identification of white matter abnormalities in multiple sclerosis : A comparison between 1.5 T and 4 T. / Keiper, Mark D; Grossman, Robert I.; Hirsch, Joshua A.; Bolinger, Lizann; Ott, Ingrid L.; Mannon, Lois J.; Langlotz, Curtis P.; Kolson, Dennis L.

In: American Journal of Neuroradiology, Vol. 19, No. 8, 01.09.1998, p. 1489-1493.

Research output: Contribution to journalArticle

Keiper, MD, Grossman, RI, Hirsch, JA, Bolinger, L, Ott, IL, Mannon, LJ, Langlotz, CP & Kolson, DL 1998, 'MR identification of white matter abnormalities in multiple sclerosis: A comparison between 1.5 T and 4 T', American Journal of Neuroradiology, vol. 19, no. 8, pp. 1489-1493.
Keiper, Mark D ; Grossman, Robert I. ; Hirsch, Joshua A. ; Bolinger, Lizann ; Ott, Ingrid L. ; Mannon, Lois J. ; Langlotz, Curtis P. ; Kolson, Dennis L. / MR identification of white matter abnormalities in multiple sclerosis : A comparison between 1.5 T and 4 T. In: American Journal of Neuroradiology. 1998 ; Vol. 19, No. 8. pp. 1489-1493.
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AU - Langlotz, Curtis P.

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